Aerobic exercise training improves autonomic nervous control in patients with COPD

Autor(es)

Borghi-Silva, Audrey ^[1] ; Arena, Ross ^{[2, 3, 4]} ; Castello, Viviane ^[1] ; Simoes, Rodrigo Polaquini ^[1] ; Barreto Martins, Luis Eduardo ^[5] ; Cataii, Aparecida Maria ^[1] ; Costa, Dirceu ^[6]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Carlos, Cardiopulm Physiotherapy Lab, Nucleus Res Phys Exercise, Dept Physiotherapy, UFSCar, BR-13565905 Sao Carlos, SP - Brazil

^[2] Virginia Commonwealth Univ, Dept Internal Med, Richmond, VA - USA

^[3] Virginia Commonwealth Univ, Dept Physiol, Richmond, VA - USA

^[4] Virginia Commonwealth Univ, Dept Phys Therapy, Richmond, VA - USA

^[5] Univ Estadual Campinas, Fac Phys Educ, Exercise Physiol Lab, Campinas, SP - Brazil

^[6] Univ 9 Julho, Phys Therapy Dept, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: RESPIRATORY MEDICINE; v. 103, n. 10, p. 1503-1510, OCT 2009.
• Citações Web of Science: 52

Resumo

Objectives: Autonomic modulation is adversely impacted in patients with chronic obstructive pulmonary disease (COPD). The purpose of the present investigation is to assess the effects of a 6-week aerobic exercise training program on autonomic modulation of heart rate in patients with COPD. Methods: Forty patients of both sexes with moderate-to-severe COPD were randomly allocated to aerobic exercise training (PT, n = 20) or to usual care (Control, n = 20). The training program consisted of tower and upper limb stretching and 30 min of treadmill. exercise, 3 times per week for a 6-week period. Physiological data during symptom-limited exercise testing and the six-minute walk test (6MWT) were assessed. In addition, R-R intervals were obtained at rest and during the 6MWT. Heart rate variability was analyzed by time (rMSSD and SDNN index) and frequency domains (high frequency - HF, low frequency - LF and HF/LF ratio). Results: Peak oxygen consumption significantly improved in the training group only (p < 0.05). Moreover, the training group demonstrated significant improvements (p < 0.05) in blood lactate, minute ventilation, dyspnea at peak exercise, sympathetic activity, and parasympathetic activity at rest and during submaximal exercise. Lastly, a positive and significant correlation was found between change in 6MWT distance and rMSSD index (r = 0.65 and p = 0.001). Conclusions: Neural control of heart rate, in addition to other clinically valuable measures, is positively altered in moderate-severe COPD patients following 6 weeks of aerobic exercise training. The improvement in submaximal performance after exercise training was associated with parasympathetic activity. Published by Elsevier Ltd. (AU)

• Processo FAPESP: 05/59427-7 - Efeito da modulação autonômica cardíaca em pacientes submetidos à cirurgia de revascularização do miocárdio e programa de fisioterapia: fase I da reabilitação cardiovascular
• Beneficiário: Audrey Borghi Silva
• Modalidade de apoio: Auxílio à Pesquisa - Regular