Pyrodysinoic Acid Derivatives from the Marine Sponge Dysidea robusta

Autor(es)

Williams, David E. ^{[1, 2]} ; Marques, Suzi O. ^[3] ; Hajdu, Eduardo ^[4] ; Peixinho, Solange ^[5] ; Andersen, Raymond J. ^{[1, 2]} ; Berlinck, Roberto G. S. ^[3]

Afiliação do(s) autor(es)

^[1] Univ British Columbia, Dept Chem, Vancouver, BC V6T 1Z1 - Canada

^[2] Univ British Columbia, Dept Earth & Ocean Sci, Vancouver, BC V6T 1Z1 - Canada

^[3] Univ Sao Paulo, Inst Quim Sao Carlos, BR-13560970 Sao Carlos, SP - Brazil

^[4] Univ Fed Rio de Janeiro, Museu Nacl, BR-20940040 Rio De Janeiro - Brazil

^[5] Univ Fed Bahia, Dept Biol, Salvador, BA - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Natural Products; v. 72, n. 9, p. 1691-1694, SEP 2009.
• Citações Web of Science: 9

Resumo

Three new nitrogen-containing terpenes related to pyrodysinoic acid (1) have been isolated from the sponge Dysidea robusta collected in Brazil. Isopyrodysinoic acid (2), 13-hydroxyisopyrodysinoic acid (3), and pyrodysinoic acid B (4) were obtained from the crude extract of D. robusta and identified by analysis of spectroscopic data. Pyrodysinoic acid B (4) is the first furodysin or furodysinin sesquiterpene derivative with a trans junction between the two six-membered rings of the 1,2,3,4,4a,7,8,8a-octahydro-1,1,6-trimethylnaphthalene moiety. (AU)

• Processo FAPESP: 05/60175-2 - Descoberta e desenvolvimento de potenciais agentes quimioterápicos a partir de invertebrados marinhos e de microrganismos associados
• Beneficiário: Roberto Gomes de Souza Berlinck
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Temático