Pyrodysinoic Acid Derivatives from the Marine Sponge Dysidea robusta

Author(s)

Williams, David E. ^{[1, 2]} ; Marques, Suzi O. ^[3] ; Hajdu, Eduardo ^[4] ; Peixinho, Solange ^[5] ; Andersen, Raymond J. ^{[1, 2]} ; Berlinck, Roberto G. S. ^[3]

Affiliation

^[1] Univ British Columbia, Dept Chem, Vancouver, BC V6T 1Z1 - Canada

^[2] Univ British Columbia, Dept Earth & Ocean Sci, Vancouver, BC V6T 1Z1 - Canada

^[3] Univ Sao Paulo, Inst Quim Sao Carlos, BR-13560970 Sao Carlos, SP - Brazil

^[4] Univ Fed Rio de Janeiro, Museu Nacl, BR-20940040 Rio De Janeiro - Brazil

^[5] Univ Fed Bahia, Dept Biol, Salvador, BA - Brazil

• Document type: Journal article
• Source: Journal of Natural Products; v. 72, n. 9, p. 1691-1694, SEP 2009.
• Web of Science Citations: 9

Abstract

Three new nitrogen-containing terpenes related to pyrodysinoic acid (1) have been isolated from the sponge Dysidea robusta collected in Brazil. Isopyrodysinoic acid (2), 13-hydroxyisopyrodysinoic acid (3), and pyrodysinoic acid B (4) were obtained from the crude extract of D. robusta and identified by analysis of spectroscopic data. Pyrodysinoic acid B (4) is the first furodysin or furodysinin sesquiterpene derivative with a trans junction between the two six-membered rings of the 1,2,3,4,4a,7,8,8a-octahydro-1,1,6-trimethylnaphthalene moiety. (AU)

• FAPESP's process: 05/60175-2 - Discovery and development of potential chemotherapeutic agents based on marine invertebrates and associated micro-organisms
• Grantee: Roberto Gomes de Souza Berlinck
• Support Opportunities: BIOTA-FAPESP Program - Thematic Grants