Microbiological profile of untreated subjects with localized aggressive periodontitis

Autor(es)

Faveri, Marcelo ^[1] ; Figueiredo, Luciene Cristina ^[1] ; Duarte, Poliana Mendes ^[1] ; Mestnik, Maria Josefa ^[1] ; Alves Mayer, Marcia Pinto ^[2] ; Feres, Magda ^[1]

Afiliação do(s) autor(es)

^[1] Univ Guarulhos, Dent Res Div, Dept Periodontol, Guarulhos, SP - Brazil

^[2] Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF CLINICAL PERIODONTOLOGY; v. 36, n. 9, p. 739-749, SEP 2009.
• Citações Web of Science: 91

Resumo

Aim The microbial profile of localized aggressive periodontitis (LAgP) has not yet been determined. Therefore, the aim of this study was to evaluate the subgingival microbial composition of LAgP. Material and Methods One hundred and twenty subjects with LAgP (n=15), generalized aggressive periodontitis (GAgP, n=25), chronic periodontitis (ChP, n=30) or periodontal health (PH, n=50) underwent clinical and microbiological assessment. Nine subgingival plaque samples were collected from each subject and analysed for their content of 38 bacterial species using checkerboard DNA-DNA hybridization. Results Red complex and some orange complex species are the most numerous and prevalent periodontal pathogens in LAgP. The proportions of Aggregatibacter actinomycetemcomitans were elevated in shallow and intermediate pockets of LAgP subjects in comparison with those with GAgP or ChP, but not in deep sites. This species also showed a negative correlation with age and with the proportions of red complex pathogens. The host-compatible Actinomyces species were reduced in LAgP. Conclusion A. actinomycetemcomitans seems to be associated with the onset of LAgP, and Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, Campylobacter gracilis, Eubacterium nodatum and Prevotella intermedia play an important role in disease progression. Successful treatment of LAgP would involve a reduction in these pathogens and an increase in the Actinomyces species. (AU)

• Processo FAPESP: 06/52890-6 - Identificação de possíveis organismos associados à periodontite agressiva por análise clonal de 16S rRNA
• Beneficiário: Marcia Pinto Alves Mayer
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 05/59443-2 - Identificação de possíveis organismos associados à periodontite agressiva por análise clonal de 16SrRNA
• Beneficiário: Marcelo de Faveri
• Modalidade de apoio: Bolsas no Brasil - Doutorado