Evaluation of anti-inflammatory effect of synthetic 1,5-bis(4-acetoxy-3-methoxyphenyl)-1,4-pentadien-3-one, HB2

Autor(es)

Paulino, Niraldo ^[1] ; Rodrigues, Naiara Carvalho ^[1] ; Pardi, Paulo Celso ^[1] ; Pablo Quincoces Suarez, Jose Agustin ^[2] ; dos Santos, Reginaldo Pereira ^[2] ; Scremin, Amarilis ^[3] ; Vogel, Christian ^[4] ; Feist, Holger ^[4] ; Michalik, Dirk ^[5]

Afiliação do(s) autor(es)

^[1] Univ Bandeirante Sao Paulo, Grp Pesquisa & Desenvolvimento Biomed Amentos BIO, Sao Paulo - Brazil

^[2] Univ Bandeirante Sao Paulo, Lab Sintese Organ, Sao Paulo - Brazil

^[3] Univ Fed Santa Catarina, Lab Controle Qualidade, Florianopolis, SC - Brazil

^[4] Univ Rostock, Inst Chem, D-2500 Rostock 1 - Germany

^[5] Leibniz Inst Katalyse, Rostock - Germany

• Tipo de documento: Artigo Científico
• Fonte: Bioorganic & Medicinal Chemistry; v. 17, n. 13, p. 4290-4295, JUL 1 2009.
• Citações Web of Science: 10

Resumo

This work describes the synthesis and anti-inflammatory properties of a pentadienone derivative, HB2. The treatment with HB2 produced anti-oedematogenic, anti-inflammatory and antinociception without change locomotors performance. Finally, HB2 reduced the nitric oxide and prostaglandin E(2) production on RAW 264.7 cells stimulated with LPS without changing the cell viability. Taken together, our results show, for the first time, that HB2 can modulate the inflammatory response when administered to mice. (C) 2009 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 04/11351-0 - Sintese de heterociclos prenilados a partir de produtos naturais.
• Beneficiário: José Agustín Pablo Quincoces Suárez
• Modalidade de apoio: Auxílio à Pesquisa - Regular