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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Early Onset Obsessive-Compulsive Disorder With and Without Tics

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Autor(es):
de Mathis, Maria Alice ; Diniz, Juliana B. ; Shavitt, Roseli G. [1] ; Torres, Albina R. [2] ; Ferrao, Ygor A. [3] ; Fossaluza, Victor ; Pereira, Carlos [4] ; Miguel, Euripedes C. [5] ; do Rosario, Maria Conceicao [6]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Sao Paulo Med Sch, Dept Psychiat, Sao Paulo - Brazil
[2] Botucatu Med Sch, Dept Neurol Psychol & Psychiat, Sao Paulo - Brazil
[3] Ctr Univ Metodista, Porto Alegre Inst, Porto Alegre, RS - Brazil
[4] Univ Sao Paulo, Math & Stat Inst, BR-05403010 Sao Paulo - Brazil
[5] Sao Paulo Med Sch, Inst Psychiat, Sao Paulo - Brazil
[6] Univ Fed Sao Paulo, Dept Psychiat, Sao Paulo - Brazil
Número total de Afiliações: 6
Tipo de documento: Artigo Científico
Fonte: CNS SPECTRUMS; v. 14, n. 7, p. 362-370, JUL 2009.
Citações Web of Science: 28
Resumo

Introduction: Research suggests that obsessive-compulsive disorder (OCD) is not a unitary entity, but rather a highly heterogeneous condition, with complex and variable clinical manifestations. Objective: The aims of this study were to compare clinical and demographic characteristics of OCD patients with early and late age of onset of obsessive-compulsive symptoms (OCS); and to compare the same features in early onset OCD with and without tics. The independent impact of age at onset and presence of tics on comorbidity patterns was investigated. Methods: Three hundred and thirty consecutive outpatients meeting Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria for OCD were evaluated: 160 patients belonged to the ``early onset{''} group (EOG): before 11 years of age, 75 patients had an ``intermediate onset{''} (IOG), and 95 patients were from the ``late onset{''} group (LOG): after 18 years of age. From the 160 EOG, 60 had comorbidity with tic disorders. The diagnostic instruments used were: the Yale-Brown Obsessive Compulsive Scale and the Dimensional Yale-Brown Obsessive Compulsive Scale (DY-BOCS), Yale Global Tics Severity Scale; and Structured Clinical Interview for DSM-IV Axis I Disorders-patient edition. Statistical tests used were: Mann-Whitney, full Bayesian significance test, and logistic regression. Results: The EOG had a predominance of males, higher frequency of family history of OCS, higher mean scores on the ``aggression/violence{''} and ``miscellaneous{''} dimensions, and higher mean global DY-BOCS scores. Patients with EOG without tic disorders presented higher mean global DY-BOCS scores and higher mean scores in the ``contamination/cleaning{''} dimension. Conclusion: The current results disentangle some of the clinical overlap between early onset OCD with and without tics. CNS Spectr. 2009; 14(7):362-370 (AU)

Processo FAPESP: 04/11462-6 - Características fenotípicas do TOC com idade de início precoce dos sintomas
Beneficiário:Maria Alice Simões de Mathis
Linha de fomento: Bolsas no Brasil - Mestrado