Distinct Gender-related Sleep Pattern in an Acute Model of TMJ Pain

Autor(es)

Schutz, T. C. B. ^[1] ; Andersen, M. L. ^[1] ; Silva, A. ^[1] ; Tufik, S. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Escola Paulista Med, Dept Psychobiol, BR-04024002 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF DENTAL RESEARCH; v. 88, n. 5, p. 471-476, MAY 2009.
• Citações Web of Science: 8

Resumo

Since it is recognized that acute inflammation of the temporomandibular joint results in sleep disturbances in male rats, and that the orofacial region may display a site-specific effect of ovarian hormones on nociception, we hypothesized that distinct genders would respond differently when subjected to this inflammatory acute orofacial pain. Sleep was monitored after injection of saline/Freund's adjuvant into the temporomandibular joint in male and female (proestrus and diestrus phases) rats. Progesterone and stress-related hormones were also assessed. In males, Freund's adjuvant induced a significant nociceptive response and sleep disturbances. Behavior and sleep architecture in the females remained unaffected. Our results suggest that females and males present distinct responses to an acute model of orofacial pain. (AU)

• Processo FAPESP: 07/56620-6 - Efeitos da privação de sono paradoxal na sensibilidade dolorosa em ratos machos e fêmeas
• Beneficiário: Andressa da Silva de Mello
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 98/14303-3 - Center for Sleep Studies
• Beneficiário: Sergio Tufik
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs