| Full text | |
| Author(s): |
Total Authors: 4
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| Affiliation: | [1] Univ Fed Sao Paulo, Escola Paulista Med, Dept Psychobiol, BR-04024002 Sao Paulo - Brazil
Total Affiliations: 1
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| Document type: | Journal article |
| Source: | JOURNAL OF DENTAL RESEARCH; v. 88, n. 5, p. 471-476, MAY 2009. |
| Web of Science Citations: | 8 |
| Abstract | |
Since it is recognized that acute inflammation of the temporomandibular joint results in sleep disturbances in male rats, and that the orofacial region may display a site-specific effect of ovarian hormones on nociception, we hypothesized that distinct genders would respond differently when subjected to this inflammatory acute orofacial pain. Sleep was monitored after injection of saline/Freund's adjuvant into the temporomandibular joint in male and female (proestrus and diestrus phases) rats. Progesterone and stress-related hormones were also assessed. In males, Freund's adjuvant induced a significant nociceptive response and sleep disturbances. Behavior and sleep architecture in the females remained unaffected. Our results suggest that females and males present distinct responses to an acute model of orofacial pain. (AU) | |
| FAPESP's process: | 98/14303-3 - Center for Sleep Studies |
| Grantee: | Sergio Tufik |
| Support Opportunities: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |