Chicken Dapper Genes Are Versatile Markers for Mesodermal Tissues, Embryonic Muscle Stem Cells, Neural Crest Cells, and Neurogenic Placodes

Autor(es)

Alvares, Lucia Elvira ^[1] ; Winterbottom, Farrah Leigh ^[2] ; Sobreira, Debora Rodrigues ^[1] ; Xavier-Neto, Jose ^[3] ; Schubert, Frank Richard ^[4] ; Dietrich, Susanne ^[5]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Inst Biol, Dept Histol & Embryol, Sao Paulo - Brazil

^[2] Kings Coll London, Inst Dent, Dept Cranofacial Dev, London WC2R 2LS - England

^[3] HC FMUSP, Lab Gen&oecutet & Cardiol Mol InCor, Sao Paulo - Brazil

^[4] Univ Portsmouth, Sch Biol Sci, Inst Biomed & Biomol Sci, Portsmouth, Hants - England

^[5] Kings Coll London, Sch Biomed & Hlth Sci, London SE1 1UL - England

• Tipo de documento: Artigo Científico
• Fonte: DEVELOPMENTAL DYNAMICS; v. 238, n. 5, p. 1166-1178, MAY 2009.
• Citações Web of Science: 8

Resumo

Dapper (Dpr) proteins are context-dependent regulators of Wnt and Tgf beta signaling. However, although inroads into their molecular properties have been made, their expression and biological function are not understood. Searching for avian Dpr genes, we found that the chicken harbors a Dpr1 and a Dpr2 paralogue only. The genes are expressed in distinct patterns at gastrulation, neurulation, and organogenesis stages of development with key expression domains being the posterior primitive streak, anterior node and notochord, presomitic mesoderm (segmental plate), lateral and cardiac mesoderm, limb mesenchyme, and neurogenic placodes for Dpr1, and anterior primitive streak, node, epithelial somites, embryonic muscle stem cells, oral ectoderm and endoderm, neural crest cells, limb ectoderm, and lung buds for Dpr2. Expression overlaps in a few tissues; however, in several tissues, expression is complementary. Developmental Dynamics 238:1166-1178, 2009. (C) 2009 Wiley-Liss, Inc. (AU)

• Processo FAPESP: 06/50843-0 - Evolução e desenvolvimento das câmaras cardíacas
• Beneficiário: José Xavier Neto
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 06/05892-3 - Estudo das funções dos genes da família Frodo/Dapper na embriogênese dos vertebrados
• Beneficiário: Lúcia Elvira Álvares
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores