Prefrontal afferents to the dorsal raphe nucleus in the rat

Autor(es)

Goncalves, Luciano ^{[1, 2]} ; Nogueira, Maria Ines ^[1] ; Shammah-Lagnado, Sara Joyce ^[2] ; Metzger, Martin ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Anat, Inst Biomed Sci, BR-05508900 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Dept Physiol & Biophys, Inst Biomed Sci, BR-05508900 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Brain Research Bulletin; v. 78, n. 4-5, p. 240-247, MAR 16 2009.
• Citações Web of Science: 36

Resumo

The prefrontal cortex (PFC) receives strong inputs from monoaminergic cell groups in the brainstem and also sends projections to these nuclei. Recent evidence suggests that the PFC exerts a powerful top-down control over the dorsal raphe nucleus (DR) and that it may be involved in the actions of pharmaceutical drugs and drugs of abuse. In the light of these findings, the precise origin of prefrontal inputs to DR was presently investigated by using the cholera toxin subunit b (CTb) as retrograde tracer. All the injections placed in DR produced retrograde labeling in the medial, orbital, and lateral divisions of the PFC as well as in the medial part of the frontal polar cortex. The labeling was primarily located in layer V. Remarkably, labeling in the medial PFC was denser in its ventral part (infralimbic and ventral prelimbic cortices) than in its dorsal part (dorsal prelimbic, anterior cingulate and medial precentral cortices). After injections in the rostral or caudal DR, the largest number of labeled neurons was observed in the medial PFC, whereas after injections in the mid-rostrocaudal DR, the labeled neurons were more homogeneously distributed in the three main PFC divisions. A cluster of labeled neurons also was observed around the apex of the rostral pole of the accumbens, especially after rostral and mid-rostrocaudal DR injections. Overall, these results confirm the existence of robust preftontal projections to DR, mainly derived from the ventral part of the medial PFC, and underscore a substantial contribution of the frontal polar cortex. (C) 2008 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 06/53068-8 - Organização das projeções do córtex pré-frontal para o núcleo dorsal da rafe
• Beneficiário: Luciano Gonçalves
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 04/06790-4 - Composição de receptores de dopamina e glutamato nos neurônios imunopositivos para a fosfoproteina neuronal DARPP-32 no córtex pré-frontal de ratos
• Beneficiário: Martin Andreas Metzger
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 05/51607-6 - Conexoes eferentes dos nucleos mediais da area tegmental ventral no rato.
• Beneficiário: Sara Joyce Shammah-Lagnado
• Modalidade de apoio: Auxílio à Pesquisa - Regular