| Texto completo | |
| Autor(es): |
Costa-Junior, Helio Miranda
;
Suetsugu, Mariana J.
;
Krieger, Jose Eduardo
;
Schechtman, Deborah
[1]
Número total de Autores: 4
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Sch Med, Heart Inst InCor, Lab Genet & Mol Cardiol, BR-05403000 Sao Paulo - Brazil
Número total de Afiliações: 1
|
| Tipo de documento: | Artigo de Revisão |
| Fonte: | Regulatory Peptides; v. 153, n. 1-3, p. 11-18, FEB 25 2009. |
| Citações Web of Science: | 6 |
| Resumo | |
Protein kinases are key drug targets for several diseases. However, despite large efforts, the development of drugs that are specific for these kinases has been a great challenge. The discovery that protein-protein interactions can be mediated by small linear sequences has invigorated the bioinformatics field and there are increasing efforts to create computer programs that identify and characterize linear sequences responsible for protein-protein interactions. The development of peptides as modulators of target protein activity is facilitated by in silico approaches. There are numerous applications for peptide modulators of protein-protein interactions and peptide modulators of kinase activity. Peptide modulators may be used either as tools to elucidate specific signaling pathways, as drug leads, or as drugs themselves. In the present review we will discuss the development of such peptide modulators and some of their applications. (C) 2008 Elsevier B.V. All rights reserved. (AU) | |
| Processo FAPESP: | 05/54188-4 - Determinação do papel da proteína quinase C na diferenciação e proliferação |
| Beneficiário: | Deborah Schechtman |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |
| Processo FAPESP: | 06/52062-6 - Caracterização das diferentes isoenzimas das proteínas cinases C e seus substratos em células tronco embrionárias murinas não diferenciadas |
| Beneficiário: | Helio Miranda Costa Junior |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |