Revised Diagnostic Criteria for Vogt-Koyanagi-Harada Disease: Considerations on the Different Disease Categories

Autor(es)

Gaspar Carvalho Da Silva, Felipe Theodoro Bezerra ^[1] ; Damico, Francisco Max ^[1] ; Marin, Maria Lucia ^[2] ; Goldberg, Anna Carla ^[2] ; Hirata, Carlos Eduardo ^[1] ; Takiuti, Pedro Henrique ; Olivalves, Edilberto ^[1] ; Yamamoto, Joyce Hisae ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Med, Uveitis Serv, Dept Ophthalmol, Hosp Clin, Sao Paulo - Brazil

^[2] Heart Inst InCor, Immunol Lab, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: AMERICAN JOURNAL OF OPHTHALMOLOGY; v. 147, n. 2, p. 339-345, FEB 2009.
• Citações Web of Science: 29

Resumo

PURPOSE: To evalulate the applicability of the Revised Diagnostic Criteria for Vogt-Koyanagi-Harada (VKH) disease to Brazilian patients and to verify the association between different disease categories, clinical parameters, and the presence of HLA-DRB1{*}0405. DESIGN: A retrospective observational case series. METHODS: Medical charts of 67 patients (10 to 64 years in age; 12 men and 55 women), from the Uveitis Service, Hospital das Clinicas, University of Sao Paulo School of Medicine (HCFMUSP), Sao Paulo, Brazil were reviewed. Patients, previously diagnosed with VKH disease using criteria proposed by the American Uveitis Society, underwent retrospective classification based on the Revised Diagnostic Criteria. The degree of concordance was assessed. At presentation, 46 patients (69%) were in the early phase. In this group, the mean time from disease onset to treatment was 15 days (range, one to 30 days). Forty-eight patients (72%) were typed for HLA-DRB1{*}0405 by polymerase chain reaction-sequence specific primer and polymerase chain reaction,sequence, specific oligonucleotides primer. Disease categories, phase at initial presentation, and ocular complications were analyzed. RESULTS: There was a 100% of concordance between the two criteria. Disease was classified as complete in 10 patients (15%), incomplete in 37 patients (55%), and probable in 20 patients (30%). In each group, respectively, 90%, 76%, and 45% were in the early phase at presentation (P = .017). There was no association between disease categories, the presence of HLA-DRB1{*}0405, and clinical parameters. CONCLUSION. The Revised Diagnostic Criteria proved useful for diagnosis of VKH disease in Brazilian patients. The present retrospective study did not find any association between disease category and severity parameters. To better understand the relevance of disease categories, a minimum follow-up period to categorize patients should be included in future prospective studies. (Am J Ophthalmol 2009;147:339-345. (C) 2009 by Elsevier Inc. All rights reserved.) (AU)

• Processo FAPESP: 07/57154-9 - Função visual em pacientes com doença Vogt-Koyanagi-Harada: fase crônica
• Beneficiário: Felipe Theodoro Bezerra Gaspar Carvalho da Silva
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto