Metallochlorophylls of magnesium, copper and zinc: evaluation of the influence of the first coordination sphere on their solvatochromism and aggregation properties

Autor(es):Mostrar menos -

Moreira, Leonardo M. ^[1] ; Lima, Adriana ^[1] ; Soares, Rafael R. S. ^[2] ; Batistela, Vagner R. ^[2] ; Gerola, Adriana P. ^[2] ; Hioka, Noboru ^[2] ; Bonacin, Juliano A. ^[3] ; Severino, Divinomar ^[3] ; Baptista, Mauricio S. ^[3] ; da Hora Machado, Antonio E. ^[4] ; Rodrigues, Maira R. ^[1] ; Codognoto, Lucia ^[1] ; de Oliveira, Hueder P. M. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Camilo Castelo Branco, BR-12247004 Sao Jose Dos Campos - Brazil

^[2] Univ Estadual Maringa, Dept Quim, BR-87020900 Maringa, Parana - Brazil

^[3] Univ Sao Paulo, Dept Bioquim, Inst Quim, BR-05508900 Sao Paulo - Brazil

^[4] Univ Fed Uberlandia, Inst Quim, BR-38408100 Uberlandia, MG - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of the Brazilian Chemical Society; v. 20, n. 9, p. 1653-1658, 2009.
• Citações Web of Science: 13

Resumo

In this study the role of different metal centers (magnesium, zinc and copper) on the enhancement of the hydrophilic character of metallochlorophylls, was evaluated. The solvatochromism as well as the aggregation process for these compounds in water/ethanol mixtures at different volume ratios were evaluated using Fluorescence, and Resonant Light Scattering (RLS) measurements, aiming to characterize the behavior of these compounds. Independently on the studied metallochlorophyll, the presence of at least 60% of water results in a considerable increase in the fluorescence emission, probably a direct consequence of a lower aggregation of these compounds, which is confirmed by the results from RLS measurements. Additionally, the results suggest that magnesium and zinc chlorophyll should be promising phototherapeutic agents for Photodynamic Therapy. (AU)

• Processo FAPESP: 08/50588-6 - Eletrodos de ouro modificados por monocamadas auto-organizadas aplicados à determinação de pesticidas
• Beneficiário: Lucia Codognoto de Oliveira
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 02/00272-6 - Estudo e caracterização de polissacarídeos hidrofobicamente modificados
• Beneficiário: Maira Regina Rodrigues Magini
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 06/56701-3 - Estudo de processos de agregacao em moleculas com potencial aplicacao em terapia fotodinamica.
• Beneficiário: Hueder Paulo Moisés de Oliveira
• Modalidade de apoio: Auxílio à Pesquisa - Regular