| Texto completo | |
| Autor(es): |
Popi, Ana F.
[1]
;
Motta, Fabiana L. T.
[2]
;
Mortara, Renato A.
[1]
;
Schenkman, Sergio
[1]
;
Lopes, Jose D.
[1]
;
Mariano, Mario
[1]
Número total de Autores: 6
|
| Afiliação do(s) autor(es): | [1] Univ Fed Sao Paulo, Dept Microbiol Immunol & Parasitol, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, CEDEME Ctr Desenvolvimento Modelos Expt Med & Bio, Sao Paulo - Brazil
Número total de Afiliações: 2
|
| Tipo de documento: | Artigo Científico |
| Fonte: | IMMUNOLOGY; v. 126, n. 1, p. 114-122, JAN 2009. |
| Citações Web of Science: | 34 |
| Resumo | |
We previously demonstrated that B-1b cells can undergo differentiation to acquire a mononuclear phagocyte phenotype upon attachment to substrate in vitro. Here we followed the expression of surface markers and transcription factors during this differentiation. B-1b cells spontaneously express both myeloid and lymphoid restricted transcription factors. When induced to differentiate into a phagocyte, the lymphoid genes E box protein (E2A), early B-cell factor (EBF), paired box 5 (Pax5) are down-modulated, while expression of genes related to myeloid commitment is sustained. Furthermore, B-1b cell-derived phagocytes (B-1CDPs) decrease immunoglobulin M (IgM) expression but retain the expression of the heavy chain variable gene VH11 or VH12, an immunoglobulin gene rearrangement predominantly expressed by B-1 cells. The maintenance of lymphoid characteristics in B-1CDPs characterizes a unique type of phagocyte, not related to monocyte-derived macrophages. (AU) | |
| Processo FAPESP: | 04/14837-0 - Fatores epigeneticos e expressao promiscua de genes linfoides e mieloides por celulas b-1. |
| Beneficiário: | Ana Flavia Popi |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 04/08506-1 - Células B-1: origem, diferenciação e participação na inflamação, cicatrização e rejeição de enxerto |
| Beneficiário: | Mario Mariano |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |