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Annexin A1 subcellular expression in laryngeal squamous cell carcinoma

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Autor(es):
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Alves, V. A. F. [1] ; Nonogaki, S. [2] ; Cury, P. M. [3] ; Wuensch-Filho, V. [4] ; de Carvalho, M. B. [5] ; Michaluart-Junior, P. [6] ; Moyses, R. A. [6] ; Curioni, O. A. [5] ; Figueiredo, D. L. A. [7] ; Scapulatempo-Neto, C. [1] ; Parra, E. R. [1] ; Polachini, G. M. [8] ; Silistino-Souza, R. [9] ; Oliani, S. M. [9] ; Silva-Junior, W. A. [10] ; Nobrega, F. G. [11] ; Tajara, E. H. [8, 12] ; Zago, M. A. [13] ; GENCAPO, Head \& Neck Genome Project
Número total de Autores: 19
Afiliação do(s) autor(es):
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[1] Univ Sao Paulo, Sch Med, Dept Pathol, BR-09500900 Sao Paulo - Brazil
[2] Adolfo Lutz Inst, Div Pathol, Sao Paulo - Brazil
[3] FAMERP, Sch Med, Dept Pathol, BR-15090000 Sao Jose Do Rio Preto, SP - Brazil
[4] Univ Sao Paulo, Sch Publ Hlth, Dept Epidemiol, BR-09500900 Sao Paulo - Brazil
[5] Heliopolis Hosp, Dept Head & Neck Surg, Sao Paulo - Brazil
[6] Univ Sao Paulo, Sch Med, Dept Surg, Div Head & Neck Surg, BR-09500900 Sao Paulo - Brazil
[7] USP, Sch Med Ribeirao Preto, Dept Ophthalmol Otorhinolaryngol & Head & Neck Su, Sao Jose Do Rio Preto - Brazil
[8] FAMERP, Sch Med, Dept Mol Biol, BR-15090000 Sao Jose Do Rio Preto, SP - Brazil
[9] UNESP, Sao Paulo State Univ, IBILCE, Dept Biol, Inst Biociencias Letras & Ciencias Exatas, Sao Jose Do Rio Preto - Brazil
[10] USP, Sch Med Ribeirao Preto, Dept Genet, Sao Jose Dos Campos - Brazil
[11] UNESP, Sao Paulo State Univ, Sao Jose Dos Campos Dent Sch, Dept Biosci & Oral Diag, Sao Jose Dos Campos - Brazil
[12] Univ Sao Paulo, Inst Biosci, Dept Genet & Evolutionary Biol, Sao Paulo, SP - Brazil
[13] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Clin Med, Sao Paulo, SP - Brazil
Número total de Afiliações: 13
Tipo de documento: Artigo Científico
Fonte: Histopathology; v. 53, n. 6, p. 715-727, DEC 2008.
Citações Web of Science: 20
Resumo

Annexin A1 (ANXA1) is a soluble cytoplasmic protein, moving to membranes when calcium levels are elevated. ANXA1 has also been shown to move to the nucleus or outside the cells, depending on tyrosine-kinase signalling, thus interfering in cytoskeletal organization and cell differentiation, mostly in inflammatory and neoplastic processes. The aim was to investigate subcellular patterns of immunohistochemical expression of ANXA1 in neoplastic and non-neoplastic samples from patients with laryngeal squamous cell carcinomas (LSCC), to elucidate the role of ANXA1 in laryngeal carcinogenesis. Serial analysis of gene expression experiments detected reduced expression of ANXA1 gene in LSCC compared with the corresponding non-neoplastic margins. Quantitative polymerase chain reaction confirmed ANXA1 low expression in 15 LSCC and eight matched normal samples. Thus, we investigated subcellular patterns of immunohistochemical expression of ANXA1 in 241 paraffin-embedded samples from 95 patients with LSCC. The results showed ANXA1 down-regulation in dysplastic, tumourous and metastatic lesions and provided evidence for the progressive migration of ANXA1 from the nucleus towards the membrane during laryngeal tumorigenesis. ANXA1 dysregulation was observed early in laryngeal carcinogenesis, in intra-epithelial neoplasms; it was not found related to prognostic parameters, such as nodal metastases. (AU)

Processo FAPESP: 02/01520-3 - Head and neck and esophageal squamous cell carcinoma: biomarkers derived from genomics and proteomics
Beneficiário:Eloiza Helena Tajara da Silva
Linha de fomento: Auxílio à Pesquisa - Programa GENOMA
Processo FAPESP: 02/01511-4 - Expression analysis center of the clinical genome project: the role of chemokines, adhesion molecules and angiogenesis-related genes in cancer
Beneficiário:Marco Antonio Zago
Linha de fomento: Auxílio à Pesquisa - Programa GENOMA
Processo FAPESP: 02/07304-0 - Role of chemokines, adhesion molecules and angiogenesis-related genes in cancer
Beneficiário:Francisco Gorgônio Nóbrega
Linha de fomento: Auxílio à Pesquisa - Programa GENOMA
Processo FAPESP: 02/01503-1 - Uma abordagem de bioinformática para selecionar regiões gênicas como alvos análise de microarrays
Beneficiário:Wilson Araújo da Silva Junior
Linha de fomento: Auxílio à Pesquisa - Programa GENOMA
Processo FAPESP: 04/12054-9 - Busca de marcadores de agressividade em tumores de cabeça e pescoço
Beneficiário:Eloiza Helena Tajara da Silva
Linha de fomento: Auxílio à Pesquisa - Temático