Frequency, Microbial Interactions, and Antimicrobial Susceptibility of Fusobacterium nucleatum and Fusobacterium necrophorum Isolated from Primary Endodontic Infections

Autor(es)

Jacinto, Rogerio C. ^{[1, 2]} ; Montagner, Francisco ^[1] ; Signoretti, Fernanda G. C. ^[1] ; Almeida, Geovania C. ^[3] ; Gomes, Brenda P. F. A. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, UNICAMP, Endodont Div, Dept Restorat Dent, Piracicaba, SP - Brazil

^[2] Univ Fed Pelotas, Pelotas Dent Sch, Dept Semiol & Clin, Pelotas, RS - Brazil

^[3] Univ Metodista Piracicaba, UNIMEP, Piracicaba, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF ENDODONTICS; v. 34, n. 12, p. 1451-1456, DEC 2008.
• Citações Web of Science: 31

Resumo

This study assessed the prevalence and microbial interactions of Fusobacterium nucleatum and Fusobacterium necrophorum in primary endodontic infections from a Brazilian population and their antimicrobial susceptibility to some antibiotics by the E-test. One hundred ten samples from infected teeth with periapical pathologies were analyzed by culture methods. Five hundred eighty individual strains were isolated; 81.4% were strict anaerobes. F. nucleatum was found in 38 root canals and was associated with Porphyromonas gingivalis, Prevotella spp., and Eubacterium spp. F. necrophorum was found in 20 root canals and was associated with Peptostreptococcus prevotii. The simultaneous presence of F. nucleatum and F. necrophorum was not related to endodontic symptoms (p > 0.05). They were 100% susceptible to amoxicillin, amoxicillin/clavulanate, and cephaclor. Fusobacterium spp. is frequently isolated from primary-infected root canals of teeth with periapical pathologies. Amoxicillin is a useful antibiotic against F. nucleatum and F. necrophorum in endodontic infections and has been prescribed as the first choice in Brazil. (J Endod 2008;34:1451-1456) (AU)

• Processo FAPESP: 07/53164-0 - Identificacao microbiologica em dentes com necrose pulpar e sintomatologia dolorosa.
• Beneficiário: Francisco Montagner
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 06/60500-3 - Investigação da microbiota de canais radiculares infectados de dentes sintomáticos e assintomáticos por cultura e sequenciamento do gene 16S rRNA
• Beneficiário: Rogerio de Castilho Jacinto
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 07/58518-4 - Análise da microbiota de canais radiculares de dentes humanos infectados através da cultura, clonagem e sequenciamento do gene 16S rRNA
• Beneficiário: Brenda Paula Figueiredo de Almeida Gomes
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 05/55695-7 - Suscetibilidade e identificacao bacteriana in vivo de patogenos encontrados em bolsas periodontais e canais radiculares frente a diferentes medicacoes intracanais.
• Beneficiário: Brenda Paula Figueiredo de Almeida Gomes
• Modalidade de apoio: Auxílio à Pesquisa - Regular