Mutagenicity of the Musa paradisiaca (Musaceae) fruit peel extract in mouse peripheral blood cells in vivo

Autor(es)

Andrade, C. U. B. ^[1] ; Perazzo, F. F. ^[2] ; Maistro, E. L. ^[3]

Afiliação do(s) autor(es)

^[1] Univ Alfenas, Fac Enfermagem, Alfenas, MG - Brazil

^[2] Univ Fed Amapa, Lab Farmacos, Macapa, PA - Brazil

^[3] Univ Estadual Paulista, Dept Fonoaudiol, Fac Filosofia & Ciencias, Marilia, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Genetics and Molecular Research; v. 7, n. 3, p. 725-732, 2008.
• Citações Web of Science: 2

Resumo

Plants are a source of many biologically active products and nowadays they are of great interest to the pharmaceutical industry. In the present study, the mutagenic potential of the Musa paradisiaca fruit peel extract was assessed by the single-cell gel electrophoresis (SCGE) and micronucleus assays. Animals were treated orally with three different concentrations of the extract (1000, 1500, and 2000 mg/kg body weight). Peripheral blood cells of Swiss mice were collected 24 h after treatment for the SCGE assay and 48 and 72 h for the micronucleus test. The results showed that the two higher doses of the extract of M. paradisiaca induced statistically significant increases in the average numbers of DNA damage in peripheral blood leukocytes for the two higher doses and a significant increase in the mean of micronucleated polychromatic erythrocytes in the three doses tested. The polychromatic/normochromatic erythrocyte ratio scored in the treated groups was not statistically different from the negative control. The data obtained indicate that fruit peel extract from M. paradisiaca showed mutagenic effect in the peripheral blood cells of Swiss albino mice. (AU)

• Processo FAPESP: 06/57514-2 - Avaliacao do potencial mutagenico dos extratos de clusia alata e psidium cattleyanum em celulas de roedores in vivo.
• Beneficiário: Edson Luis Maistro
• Modalidade de apoio: Auxílio à Pesquisa - Regular