Persistence of vaccine immunity against hepatitis B virus and response to revaccination in vertically HIV-infected adolescents on HAART

Autor(es)

Pessoa, Silvana D. ^[1] ; Miyamoto, Maristela ^[1] ; Ono, Erika ^[1] ; Gouvea, Aida F. T. B. ^[1] ; de Moraes-Pinto, Maria Isabel ^[1] ; Succi, Regina C. M. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Div Pediat Infect Dis, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Vaccine; v. 28, n. 6, p. 1606-1612, FEB 10 2010.
• Citações Web of Science: 11

Resumo

Humoral immune response to vaccine antigens is known to be reduced in perinatally HIV-infected children. Lymphocyte immunophenotyping, humoral immunity to hepatitis B after primary immunization and response to revaccination were evaluated in 40 HIV-infected adolescents on HAART and 23 healthy age-matched controls. Anti-HBs antibody levels >= 10 mIU/mL were found in 18/40 (40.5%) of the HIV-infected adolescents and 18/23 (78.3%) of the HIV-negative adolescents from Control group. Adolescents of HIV group with anti-HBs >= 10 mIU/mL presented a higher CD4+ T cell percentage, higher naive and central memory CD8+ T cell percentages and lower immune activation markers. After revaccination, 12/18 (66.7%) adolescents of HIV group responded. Those adolescents who did not respond to revaccination presented a lower CD4+ T cell percentage, higher immune activation markers and more frequently detectable HIV viral load. We concluded that lower immune activation, higher CD4+ T cell percentage and better control of HIV replication may be associated with hepatitis B vaccine response. (C) 2009 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 04/15934-0 - Prevalencia de anticorpos contra hepatite b pos-imunizacao primaria em adolescentes infectados pelo virus da imunodeficiencia humana e resposta a revacinacao.
• Beneficiário: Regina Célia de Menezes Succi
• Modalidade de apoio: Auxílio à Pesquisa - Regular