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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Persistence of vaccine immunity against hepatitis B virus and response to revaccination in vertically HIV-infected adolescents on HAART

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Author(s):
Pessoa, Silvana D. [1] ; Miyamoto, Maristela [1] ; Ono, Erika [1] ; Gouvea, Aida F. T. B. [1] ; de Moraes-Pinto, Maria Isabel [1] ; Succi, Regina C. M. [1]
Total Authors: 6
Affiliation:
[1] Univ Fed Sao Paulo, Div Pediat Infect Dis, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Vaccine; v. 28, n. 6, p. 1606-1612, FEB 10 2010.
Web of Science Citations: 11
Abstract

Humoral immune response to vaccine antigens is known to be reduced in perinatally HIV-infected children. Lymphocyte immunophenotyping, humoral immunity to hepatitis B after primary immunization and response to revaccination were evaluated in 40 HIV-infected adolescents on HAART and 23 healthy age-matched controls. Anti-HBs antibody levels >= 10 mIU/mL were found in 18/40 (40.5%) of the HIV-infected adolescents and 18/23 (78.3%) of the HIV-negative adolescents from Control group. Adolescents of HIV group with anti-HBs >= 10 mIU/mL presented a higher CD4+ T cell percentage, higher naive and central memory CD8+ T cell percentages and lower immune activation markers. After revaccination, 12/18 (66.7%) adolescents of HIV group responded. Those adolescents who did not respond to revaccination presented a lower CD4+ T cell percentage, higher immune activation markers and more frequently detectable HIV viral load. We concluded that lower immune activation, higher CD4+ T cell percentage and better control of HIV replication may be associated with hepatitis B vaccine response. (C) 2009 Elsevier Ltd. All rights reserved. (AU)