Treatment of Resistant Obsessive-Compulsive Disorder With Ventral Capsular/Ventral Striatal Gamma Capsulotomy: A Pilot Prospective Study

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Lopes, Antonio Carlos ^{[1, 2]} ; Greenberg, Benjamin D. ^{[3, 4]} ; Noren, Georg ^{[3, 4]} ; Canteras, Miguel Montes ^[5] ; Busatto, Geraldo F. ^[1] ; de Mathis, Maria Eugenia ^[1] ; Taub, Anita ^[1] ; D'Alcante, Carina Chaubet ^[1] ; Hoexter, Marcelo Queiroz ^[6] ; Gouvea, Fernando Sauerbronn ^[1] ; Cecconi, Janaina Philippi ^[1] ; Gentil, Andre F. ^[1] ; Ferrao, Ygor Arzeno ^[1] ; Fuentes, Daniel ^[1] ; de Castro, Claudio Campi ^[7] ; Leite, Claudia C. ^[8] ; Salvajoli, Joao Victor ^[5] ; Duran, Fabio L. S. ^[1] ; Rasmussen, Steven ^{[3, 4]} ; Miguel, Euripedes Constantino ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Med, Inst Psychiat, BR-01060970 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Obsess Compuls Spectrum Disorders Program PROTOC, Dept Psychiat, Sch Med, BR-01060970 Sao Paulo - Brazil

^[3] Brown Univ, Dept Psychiat & Human Behav, Warren Alpert Med Sch, Providence, RI 02912 - USA

^[4] Brown Univ, Dept Clin Neurosci Neurosurg, Warren Alpert Med Sch, Providence, RI 02912 - USA

^[5] Hosp Santa Paulo, Inst Neurol Radiosurg, Sao Paulo - Brazil

^[6] Univ Fed Sao Paulo, Dept Psychiat, Sao Paulo - Brazil

^[7] FMUSP, Inst Heart, INCOR, Sao Paulo - Brazil

^[8] FMUSP, Dept Radiol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES; v. 21, n. 4, p. 381-392, FAL 2009.
• Citações Web of Science: 28

Resumo

A subgroup of obsessive-compulsive disorder (OCD) patients remains refractory to conventional treatments. For them, a new stereotactic radiosurgery has been recently developed: the ventral capsular/ventral striatal (VC/VS) gamma capsulotomy. The authors aim to report efficacy and adverse events of VC/VS gamma capsulotomy. Five refractory OCD patients were selected. The authors assessed OCD, anxiety and depressive symptoms, and side effects pre- and postoperatively. Three patients (60%) met response criteria 48 months after surgery. Adverse effects were episodic and transient. Ventral capsular/ventral striatal gamma capsulotomy holds therapeutic promise, with few adverse effects. (The Journal of Neuropsychiatry and Clinical Neurosciences 2009; 21:381-392) (AU)

• Processo FAPESP: 99/08560-6 - Transtorno obsessivo compulsivo e infecção estreptocócica: estudo longitudinal prospectivo
• Beneficiário: Marcos Tomanik Mercadante
• Modalidade de apoio: Bolsas no Exterior - Pesquisa