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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Treatment of Resistant Obsessive-Compulsive Disorder With Ventral Capsular/Ventral Striatal Gamma Capsulotomy: A Pilot Prospective Study

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Author(s):
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Lopes, Antonio Carlos [1, 2] ; Greenberg, Benjamin D. [3, 4] ; Noren, Georg [3, 4] ; Canteras, Miguel Montes [5] ; Busatto, Geraldo F. [1] ; de Mathis, Maria Eugenia [1] ; Taub, Anita [1] ; D'Alcante, Carina Chaubet [1] ; Hoexter, Marcelo Queiroz [6] ; Gouvea, Fernando Sauerbronn [1] ; Cecconi, Janaina Philippi [1] ; Gentil, Andre F. [1] ; Ferrao, Ygor Arzeno [1] ; Fuentes, Daniel [1] ; de Castro, Claudio Campi [7] ; Leite, Claudia C. [8] ; Salvajoli, Joao Victor [5] ; Duran, Fabio L. S. [1] ; Rasmussen, Steven [3, 4] ; Miguel, Euripedes Constantino [1]
Total Authors: 20
Affiliation:
[1] Univ Sao Paulo, Sch Med, Inst Psychiat, BR-01060970 Sao Paulo - Brazil
[2] Univ Sao Paulo, Obsess Compuls Spectrum Disorders Program PROTOC, Dept Psychiat, Sch Med, BR-01060970 Sao Paulo - Brazil
[3] Brown Univ, Dept Psychiat & Human Behav, Warren Alpert Med Sch, Providence, RI 02912 - USA
[4] Brown Univ, Dept Clin Neurosci Neurosurg, Warren Alpert Med Sch, Providence, RI 02912 - USA
[5] Hosp Santa Paulo, Inst Neurol Radiosurg, Sao Paulo - Brazil
[6] Univ Fed Sao Paulo, Dept Psychiat, Sao Paulo - Brazil
[7] FMUSP, Inst Heart, INCOR, Sao Paulo - Brazil
[8] FMUSP, Dept Radiol, Sao Paulo - Brazil
Total Affiliations: 8
Document type: Journal article
Source: JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES; v. 21, n. 4, p. 381-392, FAL 2009.
Web of Science Citations: 28
Abstract

A subgroup of obsessive-compulsive disorder (OCD) patients remains refractory to conventional treatments. For them, a new stereotactic radiosurgery has been recently developed: the ventral capsular/ventral striatal (VC/VS) gamma capsulotomy. The authors aim to report efficacy and adverse events of VC/VS gamma capsulotomy. Five refractory OCD patients were selected. The authors assessed OCD, anxiety and depressive symptoms, and side effects pre- and postoperatively. Three patients (60%) met response criteria 48 months after surgery. Adverse effects were episodic and transient. Ventral capsular/ventral striatal gamma capsulotomy holds therapeutic promise, with few adverse effects. (The Journal of Neuropsychiatry and Clinical Neurosciences 2009; 21:381-392) (AU)