Effects of bone remodelling on calcium mass transfer during haemodialysis

Autor(es)

Karohl, Cristina ^{[1, 2]} ; Paschoal, Juliana de Paiva ^[1] ; Martins de Castro, Manuel Carlos ^[1] ; Elias, Rosilene Motta ^[1] ; Abensur, Hugo ^[1] ; Romao, Jr., Joao Egidio ^[1] ; Passlick-Deetjen, Jutta ^{[3, 4]} ; Jorgetti, Vanda ^[1] ; Affonso Moyses, Rosa Maria ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med, Div Nephrol, Sao Paulo - Brazil

^[2] Univ Fed Rio Grande do Sul, Div Nephrol, Hosp Clin Porto Alegre, Porto Alegre, RS - Brazil

^[3] Fresenius Med Care, Bad Homburg - Germany

^[4] Univ Dusseldorf, Dept Nephrol, Dusseldorf - Germany

• Tipo de documento: Artigo Científico
• Fonte: Nephrology Dialysis Transplantation; v. 25, n. 4, p. 1244-1251, 2010.
• Citações Web of Science: 24

Resumo

Background. During haemodialysis, calcium balance can affect, or be affected by, mineral metabolism. However, when dialysate calcium concentration (d[Ca]) is chosen or kinetic models are employed to calculate calcium balance, bone remodelling is rarely considered. In this study, we examined whether bone remodelling affects calcium mass transfer during haemodialysis. Methods. We dialysed 23 patients using a d[Ca] of 1.0, 1.25, 1.5 or 1.75 mmol/L. Calcium mass transfer was measured and associated with remodelling bone factors. Results. Calcium balance varied widely depending on the d[Ca]. Calcium removal was -578 +/- 389, -468 +/- 563, +46 +/- 400 and +405 +/- 413 mg when a d[Ca] of 1.0, 1.25, 1.5 or 1.75 mmol/L was used, respectively (1.0 and 1.25 VS 1.5 and 1.75 mmol/L, P<0.001; 1.5 vs 1.75 mmol/L, P<0.05). Univariate analysis showed that calcium balance correlated with calcium gradient, parathyroid hormone (PTH), osteocalcin and dialysis vintage. Multivariate analysis revealed that calcium balance was dependent on calcium gradient, PTH and osteocalcin. Conclusions. These results suggest that bone remodelling could affect calcium mass transfer during haemodialysis. (AU)

• Processo FAPESP: 06/61712-4 - Influencia da remodelacao ossea na transferencia de calcio e fosforo durante hemodialise em pacientes com doenca renal cronica.
• Beneficiário: Vanda Jorgetti
• Modalidade de apoio: Auxílio à Pesquisa - Regular