Lemongrass effects on IL-1 and IL-6 production by macrophages

Autor(es)

Sforcin, J. M. ^[1] ; Amaral, J. T. ^[1] ; Fernandes, Jr., A. ^[1] ; Sousa, J. P. B. ^[2] ; Bastos, J. K. ^[2]

Afiliação do(s) autor(es)

^[1] UNESP, Biosci Inst, Dept Microbiol & Immunol, Botucatu, SP - Brazil

^[2] USP, Sch Pharmaceut Sci, Dept Pharmaceut Sci, Lab Pharmacognosy, Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: NATURAL PRODUCT RESEARCH; v. 23, n. 12, p. 1151-1159, 2009.
• Citações Web of Science: 24

Resumo

Cymbopogon citratus has been widely recognised for its ethnobotanical and medicinal usefulness. Its insecticidal, antimicrobial and therapeutic properties have been reported, but little is known about its effect on the immune system. This work aimed to investigate the in vivo effect of a water extract of lemongrass on pro-inflammatory cytokine (IL-1 and IL-6) production by macrophages of BALB/c mice. The action of lemongrass essential oil on cytokine production by macrophages was also analysed in vitro. The chemical composition of the extract and the oil was also investigated. Treatment of mice with water extract of lemongrass inhibited macrophages to produce IL-1 but induced IL-6 production by these cells. Lemongrass essential oil inhibited the cytokine production in vitro. Linalool oxide and epoxy-linalool oxide were found to be the major components of lemongrass water extract, and neral and geranial were the major compounds of its essential oil. Taken together, these data suggest an anti-inflammatory action of this natural product. (AU)

• Processo FAPESP: 06/59893-0 - Desenvolvimento de metodologia analítica e estudo fitoquímico do extrato hidroalcoólico e da fração volátil das folhas e ramos de Copaifera langsdorffii (Leguminosae: Caesalpinioideae)
• Beneficiário: João Paulo Barreto de Sousa
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 07/51419-0 - Efeito do extrato e oleos essenciais do capi-limao (cymbopogon citratus) sobre a producao de citocinas pro-inflamatorias por macrofagos.
• Beneficiário: Juliana Torres Amaral
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica