| Texto completo | |
| Autor(es): |
Puebla, Pilar
[1]
;
Oshima-Franco, Yoko
[2]
;
Franco, Luiz M.
[3]
;
Dos Santos, Marcio G.
[4]
;
da Silva, Renata V.
[2]
;
Rubem-Mauro, Leandro
[2]
;
San Feliciano, Arturo
[1]
Número total de Autores: 7
|
| Afiliação do(s) autor(es): | [1] Univ Salamanca, Fac Pharm, Dept Pharmaceut Chem, E-37007 Salamanca - Spain
[2] Sorocaba Univ, UNISO, BR-18023000 Sorocaba, SP - Brazil
[3] Univ Metodista Piracicaba, BR-13400911 Piracicaba, SP - Brazil
[4] Fed Univ Tocantins, BR-77001090 Porto Nacl, TO - Brazil
Número total de Afiliações: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Molecules; v. 15, n. 11, p. 8193-8204, 2010. |
| Citações Web of Science: | 32 |
| Resumo | |
The effect of four sub-extracts prepared from the lyophilized hydroalcoholic bark of Dipteryx alata (Leguminosae-Papilionoideae) dissolved in a methanol-water (80: 20) mixture through a liquid-liquid partition procedure has been investigated against the neuromuscular blockade of the venom of the snake Bothrops jararacussu. The active CH2Cl2 sub-extract has been extensively analyzed for its chemical constituents, resulting in the isolation of four lupane-type triterpenoids: lupeol (1), lupenone (2), 28-hydroxylup-20(29)-en-3-one (3), betulin (4), nine isoflavonoids: 8-O-methylretusin (5), 7-hydroxy-5,6,4'-trimethoxyisoflavone (6), afrormosin (8), 7-hydroxy-8,3',4'-trimethoxyisoflavone (9), 7,3'-dihydroxy-8,4'-dimethoxyisoflavone (10), odoratin (11), 7,8,3'-trihydroxy-4'-methoxyisoflavone (13), 7,8,3'-trihydroxy-6,4'-dimethoxyisoflavone (15), dipteryxin (17), one chalcone: isoliquiritigenin (7), one aurone: sulfuretin (14) and three phenolic compounds: vanillic acid (12), vanillin (16), and protocatechuic acid (18). Their chemical structures were elucidated on the basis of spectroscopic analysis, including HRMS, 1D- and 2D-NMR techniques. (AU) | |
| Processo FAPESP: | 08/11005-5 - Dipteryx alata Vogel: estudos da ação antiofídica e de toxicidade |
| Beneficiário: | Yoko Oshima Franco |
| Modalidade de apoio: | Bolsas no Exterior - Pesquisa |