Ingenamine G and cyclostellettamines G-I, K, and L from the new Brazilian species of marine sponge Pachychalina sp

Autor(es)

Oliveira, Jaine H. H. L. de ; Grube, Achim ; Kock, Matthias ; Berlinck, Roberto Gomes de Souza ^[4] ; Macedo, Mario L. ; Ferreira, Antonio G. ; Hajdu, Eduardo

• Tipo de documento: Artigo Científico
• Fonte: Journal of Natural Products; v. 67, n. 10, p. 1685-1689, Oct. 2004.
• Área do conhecimento: Ciências Exatas e da Terra - Química
• Assunto(s): Antibacterianos Antituberculosos Citotoxinas Porifera Zoologia

Resumo

The chemical investigation of the cytotoxic and antituberculosis active MeOH crude extract of the marine sponge Pachychalina sp. led to the isolation of six new nitrogenous metabolites, including ingenamine G (1), as well as a mixture of new cyclostellettamines G, H, I, K, and L (10-14) with the known cyclostellettamines A-F (4-9). Structural assignments of compound 1 were based on the analysis of MS and NMR data, while the structures of compounds 10-14 could be established by HPLC-MS/MS analysis. Ingenamine G displayed cytotoxic activity against HCT-8 (colon), B16 (leukemia), and MCF-7 (breast) cancer cell lines, antibacterial activity against Staphylococcus aureus (ATCC 25923), Escherichia coli (ATCC 25922), and four oxacilin-resistant S. aureus strains, and antimycobacterial activity against Mycobacterium tuberculosis H37Rv. (AU)

• Processo FAPESP: 01/03095-5 - Produtos de invertebrados marinhos: agentes quimioterápicos anti-proliferativos, antibióticos, e contra doenças tropicais
• Beneficiário: Roberto Gomes de Souza Berlinck
• Modalidade de apoio: Auxílio à Pesquisa - Temático