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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Ingenamine G and cyclostellettamines G-I, K, and L from the new Brazilian species of marine sponge Pachychalina sp

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Author(s):
Oliveira, Jaine H. H. L. de ; Grube, Achim ; Kock, Matthias ; Berlinck, Roberto Gomes de Souza [4] ; Macedo, Mario L. ; Ferreira, Antonio G. ; Hajdu, Eduardo
Total Authors: 7
Document type: Journal article
Source: Journal of Natural Products; v. 67, n. 10, p. 1685-1689, Oct. 2004.
Field of knowledge: Physical Sciences and Mathematics - Chemistry
Abstract

The chemical investigation of the cytotoxic and antituberculosis active MeOH crude extract of the marine sponge Pachychalina sp. led to the isolation of six new nitrogenous metabolites, including ingenamine G (1), as well as a mixture of new cyclostellettamines G, H, I, K, and L (10-14) with the known cyclostellettamines A-F (4-9). Structural assignments of compound 1 were based on the analysis of MS and NMR data, while the structures of compounds 10-14 could be established by HPLC-MS/MS analysis. Ingenamine G displayed cytotoxic activity against HCT-8 (colon), B16 (leukemia), and MCF-7 (breast) cancer cell lines, antibacterial activity against Staphylococcus aureus (ATCC 25923), Escherichia coli (ATCC 25922), and four oxacilin-resistant S. aureus strains, and antimycobacterial activity against Mycobacterium tuberculosis H37Rv. (AU)

FAPESP's process: 01/03095-5 - Natural products from marine invertebrates: potential chemotherapic anti-proliferative, antibiotic and against tropical diseases agents
Grantee:Roberto Gomes de Souza Berlinck
Support type: Research Projects - Thematic Grants