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Learning deficits induced by sleep deprivation and recovery are not associated with altered [3H] muscimol and [3H] flunitrazepam binding

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Autor(es):
Dubiela‚ F. P. ; de Oliveira‚ M. G. M. ; Moreira‚ K. D. M. ; Nobrega‚ J. N. ; Tufik‚ S. ; Hipólide‚ D. C.
Número total de Autores: 6
Tipo de documento: Artigo Científico
Fonte: Brain Research; v. 1037, n. 1/2, p. 157-163, Mar. 2005.
Área do conhecimento: Ciências da Saúde - Medicina
Assunto(s):Neurociências   Sono   Distúrbios do sono
Resumo

Several studies have shown that sleep deprivation produces deficits in learning tasks, but mechanisms underlying these effects remain unclear. Other lines of evidence indicate an involvement of brain GABA systems in cognitive processes. Here, we investigated the possibility that alterations in GABAA or benzodiazepine (BDZ) receptor binding might underlie avoidance deficits induced by sleep deprivation. Rats were deprived of sleep for 96 h using the platform method and then trained in a step-through inhibitory avoidance task, or allowed to recover sleep for 24 h before training (sleep rebound group). Thirty minutes after training, animals were given a retention test. Both sleep-deprived and sleep-recovered animals showed a significant impairment in avoidance responding compared to cage controls, and the sleep-deprived group performed significant worse than the sleep-recovered group. A separate group of animals was sacrificed either immediately after 96 h of sleep deprivation or after 96 h of sleep deprivation followed by 24 h of sleep recovery. [3H] muscimol and [3H] flunitrazepam binding were examined by quantitative autoradiography in 42 brain regions, including areas involved in cognitive processes. No significant differences among groups were found in any brain region, except for a reduction in [3H] flunitrazepam binding in the frontal cortex of sleep-recovered animals. These results confirm the deleterious effects of sleep loss on inhibitory avoidance learning, but suggest that such deficits cannot be attributed to altered GABAA or BDZ binding in brain. (AU)

Processo FAPESP: 98/14303-3 - Center for Sleep Studies
Beneficiário:Sergio Tufik
Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
Processo FAPESP: 02/12453-5 - Avaliação de receptores GABA-A após a privação de sono paradoxal e o papel do sistema gabaérgico no prejuízo de aquisição da tarefa de esquiva inibitória após a privação do sono paradoxal
Beneficiário:Francisco Paulino Dubiela
Linha de fomento: Bolsas no Brasil - Mestrado
Processo FAPESP: 01/12484-5 - Análise de receptores benzodiazepínicos em ratos submetidos à privação e recuperação de sono paradoxal
Beneficiário:Francisco Paulino Dubiela
Linha de fomento: Bolsas no Brasil - Iniciação Científica