Copper sulfate affects Nile tilapia (Oreochromis niloticus) cardiomyocytes structure and contractile function

Autor(es)

de Andrade Waldemarin, Katia Cristina ^[1] ; Alves, Rosiane Nascimento ^[2] ; Beletti, Marcelo Emilio ^[2] ; Rantin, Francisco Tadeu ^[1] ; Kalinin, Ana Lucia ^[1]

Afiliação do(s) autor(es)

^[1] Fed Univ Sao Carlos UFSCar, Lab Zoophysiol & Comparat Biochem, Dept Physiol Sci, Ctr Biol Sci & Hlth, BR-13565905 Sao Carlos, SP - Brazil

^[2] Univ Fed Uberlandia, Inst Biomed Sci, Dept Morphol, Histol Lab, BR-38400 Uberlandia, MG - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ECOTOXICOLOGY; v. 21, n. 3, p. 783-794, APR 2012.
• Citações Web of Science: 6

Resumo

Copper sulfate (CuSO4)is an inorganic chemical product worldwide used as an algaecide and a fungicide in aquaculture and agriculture and being discharged into freshwater environments where it can affect the freshwater fauna, especially fishes. The impact of copper on fish cardiac function was analyzed in two groups of Nile tilapias, Oreochromis niloticus (control group and group exposed to 1 mg l(-1) of CuSO4 for 96 h). Structural and ultra-structural changes were studied and related to perturbations of the inotropic and chronotropic responses of ventricle strips. Fish of Cu exposed group did not show significant alterations in the medium diameter and in the percentage of collagen in the cardiac myocytes when evaluated through the light microscope. However, the ultrastructural analysis revealed cellular swelling followed by mitochondrial swelling. The myofibrils did not show significant variations among groups. Force contraction was significantly decreased, and rates of time to tension increase (contraction) and decrease (relaxation) were significantly augmented after copper exposure. The results suggest that the copper sulfate impairs the oxidative mitochondrial function and consequently alters the cardiac performance of this species. (AU)

• Processo FAPESP: 04/03592-7 - Efeito do sulfato de cobre sobre a função cardíaca da tilápia tailandesa, Oreochromis niloticus
• Beneficiário: Katia Cristina de Andrade Waldemarin
• Modalidade de apoio: Bolsas no Brasil - Doutorado