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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Differential aberrant sprouting in temporal lobe epilepsy with psychiatric co-morbidities

Texto completo
Autor(es):
Kandratavicius, Ludmyla [1] ; Hallak, Jaime Eduardo [1] ; Young, Lionel Trevor [2] ; Assirati, Joao Alberto [3] ; Carlotti, Jr., Carlos Gilberto [3] ; Leite, Joao Pereira [1]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Dept Neurosci & Behav, Sch Med, BR-14049 Ribeirao Preto - Brazil
[2] Univ British Columbia, Dept Psychiat, Vancouver, BC - Canada
[3] Univ Sao Paulo, Dept Surg, Sch Med, BR-14049 Ribeirao Preto - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: PSYCHIATRY RESEARCH; v. 195, n. 3, p. 144-150, FEB 28 2012.
Citações Web of Science: 17
Resumo

Psychiatric co-morbidities in epilepsy are common in patients with temporal lobe epilepsy (TLE). Pathological alterations in TLE are well characterised; however, neuropathologic data are relatively scale regarding the association between psychiatric diseases and epilepsy. Our objective was to evaluate the clinical data of 46 adult TLE patients with and without psychiatric co-morbidities and to correlate the data with hippocampal neuronal density and mossy fiber sprouting. Accordingly, patients were grouped as follows: TLE patients without history of psychiatric disorder (TLE, n = 16), TLE patients with interictal psychosis (TLE + P, n = 14), and TLE patients with major depression (TLE + D, n = 16). Hippocampi from autopsies served as non-epileptic controls (n = 10). TLE + P exhibited significantly diminished mossy fiber sprouting and decreased neuronal density in the entorhinal cortex when compared with TLE. TLE + P showed significantly poorer results in verbal memory tasks. TLE + D exhibited significantly increased mossy fiber sprouting length when compared with TLE and TLE + P. Further, a higher proportion of TLE + D and TLE + P presented secondarily generalised seizures than did TLE. Our results indicate that TLE patients with psychiatric disorders have distinct features when compared with TLE patients without psychiatric co-morbidities and that these changes may be involved in either the manifestation or the maintenance of psychiatric co-morbidities in epilepsy. (C) 2011 Elsevier Ireland Ltd. All rights reserved. (AU)

Processo FAPESP: 07/56721-7 - Neurotrofinas na epilepsia do lobo temporal associada ou não a comorbidades psiquiátricas e no modelo animal de lítio-pilocarpina
Beneficiário:Ludmyla Kandratavicius
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 05/56447-7 - Pesquisa através de imagens por ressonância magnética de alto campo destinadas a estudos em humanos
Beneficiário:João Pereira Leite
Linha de fomento: Auxílio à Pesquisa - Programa CINAPCE - Temático