Genetic Variants in Fibrinolytic System-Related Genes in Infertile Women With and Without Endometriosis

Autor(es)

Brandes, Ariel ^[1] ; Christofolini, Denise M. ^[1] ; Cavalheiro, Camila M. ^[1] ; Vilarino, Fabia L. ^[1] ; Andre, Gustavo M. ^[1] ; Bianco, Bianca ^[1] ; Barbosa, Caio P. ^[1]

Afiliação do(s) autor(es)

^[1] Fac Med ABC, Dept Gynecol & Obstet, Div Human Reprod & Genet, BR-09060650 Santo Andre, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: GENETIC TESTING AND MOLECULAR BIOMARKERS; v. 16, n. 1, p. 54-57, JAN 2012.
• Citações Web of Science: 1

Resumo

Aims: The aim of this study was to evaluate urokinase-type plasminogen activator gene (uPA) and thrombin-activatable fibrinolysis inhibitor gene (TAFI) genotypes in a group of infertile women with and/or without endometriosis and controls. Methods: A case control study comprising 180 infertile women with endometriosis, 68 women with idiopathic infertility, and 152 fertile women as controls was carried out. Detection of uPA (C422T/rs2227564) and TAFI (G438A/rs2146881) polymorphisms was performed by TaqMan polymerase chain reaction. The results were statistically analyzed and a p-value of <0.05 was considered significant. Results: We found no association among both uPA or TAFI polymorphisms and endometriosis-related infertility (p = 0.920 and p = 0.356, respectively) or idiopathic infertility (p = 0.502 and p = 0.392, respectively) comparing to controls, even considering minimal/mild and moderate/severe endometriosis separately. Both uPA and TAFI polymorphisms were in Hardy-Weinberg equilibrium for all studied groups. The combinatory analysis of both uPA and TAFI polymorphisms to endometriosis-related infertility, idiopathic infertility, and control group showed no statistical difference to any combination. Conclusion: The data suggest that, in the Brazilian population, genetic variations in both uPA and TAFI were not relevant to endometriosis and/or infertility. (AU)

• Processo FAPESP: 10/13206-8 - Estudo de polimorfismos do sistema fibrinolítico como fator de risco para endometriose e/ou infertilidade
• Beneficiário: Ariel Brandes
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica