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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Chemosensory control by commissural nucleus of the solitary tract in rats

Texto completo
Autor(es):
Favero, Michele T. [1] ; Takakura, Ana C. [2] ; de Paula, Patricia M. [1] ; Colombari, Eduardo [1] ; Menani, Jose V. [1] ; Moreira, Thiago S. [3]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Sao Paulo State Univ UNESP, Sch Dent, Dept Physiol & Pathol, BR-14801903 Araraquara, SP - Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Dept Pharmacol, BR-05508900 Sao Paulo - Brazil
[3] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, BR-05508900 Sao Paulo - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: Respiratory Physiology & Neurobiology; v. 179, n. 2-3, p. 227-234, DEC 15 2011.
Citações Web of Science: 15
Resumo

The commissural nucleus of the solitary tract (commNTS) is a main area that receives afferent signals involved in the cardiovascular and respiratory control like those related to chemoreceptor activation. however, the importance of the commNTS for the cardiorespiratory responses to chemoreceptor activation is still controversial. In the present study, we investigated the cardiorespiratory responses to hypoxia or hypercapnia in anesthetized and conscious rats treated with injections of the GABA-A agonist muscimol into the caudal portion of the commNTS. Male :Holtzman rats (280-300g) were used. In conscious rats that had a stainless steel cannula previously implanted into the commNTS, the injection of muscimol (2 mM) into the commNTS reduced the pressor response (16 +/- 2 mmHg, vs. saline: 36 +/- 3 mmHg) and the increase in ventilation (250 +/- 17 ml/min/kg, vs. saline: 641 +/- 28 ml/min/kg) produced by hypoxia (8-10% O(2)). In urethane anesthetized rats, the injection of muscimol into the commNTS eliminated the pressor response (5 +/- 2 mmHg, vs. saline: 26 +/- 5 mmHg) and the increase in phrenic nerve discharge (PND) (20 +/- 6%, vs. saline: 149 +/- 15%) and reduced the increase in splanchnic sympathetic nerve discharge (sSND) (93 +/- 15%, vs. saline: 283 +/- 19% of baseline) produced by hypoxia. However, muscimol injected into the commNTS did not change hypercapnia (8-10% CO(2)) induced pressor response or the increase in the sSND or PND in urethane anesthetized rats or the increase in ventilation in conscious rats. The present results suggest that the cardiorespiratory responses to hypoxia are strongly dependent on the caudal portion of the commNTS, however, this area is not involved in the responses to hypercapnia. Crown Copyright (C) 2011 Published by Elsevier B.V. All rights reserved. (AU)

Processo FAPESP: 10/09776-3 - Mecanismos neurais envolvidos na geração do ritmo expiratório: possível envolvimento do núcleo retrotrapezoide e da região parafacial
Beneficiário:Ana Carolina Takakura Moreira
Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
Processo FAPESP: 06/60174-9 - Mecanismos neurais envolvidos na integração do quimioreflexo central e periférico
Beneficiário:Thiago dos Santos Moreira
Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores