Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Human polyomaviruses JC and BK in the urine of Brazilian children and adolescents vertically infected by HIV

Texto completo
Autor(es):
Mostrar menos -
Machado, Daisy Maria [1, 2] ; Fink, Maria Cristina [1] ; Pannuti, Claudio Sergio [1] ; de Menezes Succi, Regina Celia [2] ; Machado, Alessandra Aparecida [1] ; do Carmo, Fabiana Bononi [2] ; Barbosa Gouvea, Aida de Fatima [2] ; Urbano, Paulo Roberto [1] ; Beltrao, Suenia Vasconcelos [2] ; Lopes dos Santos, Isabel Cristina [2] ; Machado, Clarisse Martins [1]
Número total de Autores: 11
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Inst Med Trop Sao Paulo, Virol Lab, BR-05403000 Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Disciplina Infectol Pediat, Dept Pediat, Sao Paulo - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: Memórias do Instituto Oswaldo Cruz; v. 106, n. 8, p. 931-935, DEC 2011.
Citações Web of Science: 12
Resumo

The aim of this study was to characterize the urinary excretion of the BK (BKV) and JC (JCV) human polyomaviruses in a cohort of human immunodeficiency virus (HIV)-infected children and adolescents. One hundred and fifty-six patients were enrolled: Group I included 116 HIV-infected children and adolescents {[}median age = 11.4 years (y); range 1-22 y]; Group II included 40 non-HIV-infected healthy controls (median age = 11.37 y; range 7-16 y). Single urine samples from both groups were screened for the presence of JCV and BKV DNA by polymerase chain reaction at enrolment. The overall rate of JCV and BKV urinary excretion was found to be 24.4% and 40.4%, respectively (n = 156). Group I had urinary excretion of JCV and BKV in 27.6% and 54.3% of subjects, respectively. In contrast, Group II showed positive results for JCV in 17.5% of subjects and for BKV in 12.5% of subjects (p Pearson JCV = 0.20; p Pearson BKV < 0.0001). In Group I, there was no association between JCV/BKV shedding and age, gender or CD4 values. Patients with an HIV viral load < 50 copies/mL had a lower excretion of BKV (p < 0.001) and a trend of lower JCV excretion (p = 0.07). One patient in Group I (1/116, 0.9%) showed clinical and radiological features consistent with progressive multifocal leukoencephalopathy, suggesting that children with HIV/polyomavirus coinfection should be kept under surveillance. (AU)

Processo FAPESP: 07/06687-7 - Excreção urinária de poliomavirus em crianças e adolescentes com infecção pelo vírus da imunodeficiência humana (HIV)
Beneficiário:Daisy Maria Machado
Linha de fomento: Auxílio à Pesquisa - Regular