Sebaceous metaplasia in a canine mammary gland non-infiltrative carcinoma with myoepithelial component

Autor(es)

Grandi, Fabrizio ^{[1, 2]} ; Colodel, Marcia M. ^[2] ; Rocha, Rafael M. ^{[3, 4]} ; Sequeira, Julio L. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista, Dept Patol, Fac Med Botucatu, Botucatu, SP - Brazil

^[2] Univ Estadual Paulista, Serv Anat Patol Vet, Dept Clin Med, Fac Med Vet & Zootecnia, Botucatu, SP - Brazil

^[3] Fundacao Antonio Prudente, Sao Paulo - Brazil

^[4] Hosp AC Camargo Fund Antonio Prudente, Dept Patol Invest, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION; v. 23, n. 6, p. 1230-1233, NOV 2011.
• Citações Web of Science: 0

Resumo

Sebaceous metaplasia in canine mammary tumors is a rare condition with only 1 case documented. The current study describes a case of sebaceous metaplasia in a mammary gland carcinoma of an 8-year-old intact, nulliparous female Poodle dog with a subcutaneous tumor located in the left fifth mammary gland. The lesion measured 0.7 cm x 0.5 cm x 0.6 cm in diameter, was firm, circumscribed, painless, non-haired, and non-ulcerated, and did not adhere to deep tissues. The cut surface was non-lobulated, non-encapsulated, whitish to gray, and opaque. Histological evaluation revealed 3 different populations of cells: the first was composed of columnar to cuboidal malignant epithelial cells arranged in intraductal papillary projections, the second of myoepithelial cells associated with a myxoid stroma, and the third presenting sebaceous metaplasia similar to those previously described in both human and veterinary medicine. (AU)

• Processo FAPESP: 09/14701-5 - Caracterização da expressão gênico-protéica das proteínas de reparo MGMT e PTEN e seu potencial papel na carcinogênese e como fator prognóstico do câncer de mama
• Beneficiário: Rafael Malagoli Rocha
• Modalidade de apoio: Auxílio à Pesquisa - Regular