Sebaceous metaplasia in a canine mammary gland non-infiltrative carcinoma with myoepithelial component

Author(s)

Grandi, Fabrizio ^{[1, 2]} ; Colodel, Marcia M. ^[2] ; Rocha, Rafael M. ^{[3, 4]} ; Sequeira, Julio L. ^[2]

Affiliation

^[1] Univ Estadual Paulista, Dept Patol, Fac Med Botucatu, Botucatu, SP - Brazil

^[2] Univ Estadual Paulista, Serv Anat Patol Vet, Dept Clin Med, Fac Med Vet & Zootecnia, Botucatu, SP - Brazil

^[3] Fundacao Antonio Prudente, Sao Paulo - Brazil

^[4] Hosp AC Camargo Fund Antonio Prudente, Dept Patol Invest, Sao Paulo - Brazil

• Document type: Journal article
• Source: JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION; v. 23, n. 6, p. 1230-1233, NOV 2011.
• Web of Science Citations: 0

Abstract

Sebaceous metaplasia in canine mammary tumors is a rare condition with only 1 case documented. The current study describes a case of sebaceous metaplasia in a mammary gland carcinoma of an 8-year-old intact, nulliparous female Poodle dog with a subcutaneous tumor located in the left fifth mammary gland. The lesion measured 0.7 cm x 0.5 cm x 0.6 cm in diameter, was firm, circumscribed, painless, non-haired, and non-ulcerated, and did not adhere to deep tissues. The cut surface was non-lobulated, non-encapsulated, whitish to gray, and opaque. Histological evaluation revealed 3 different populations of cells: the first was composed of columnar to cuboidal malignant epithelial cells arranged in intraductal papillary projections, the second of myoepithelial cells associated with a myxoid stroma, and the third presenting sebaceous metaplasia similar to those previously described in both human and veterinary medicine. (AU)

• FAPESP's process: 09/14701-5 - Gene and protein expression characterization of the DNA repair proteins MGMT and PTEN and their potential role in carcinogenesis and as a prognostic factor in breast cancer
• Grantee: Rafael Malagoli Rocha
• Support Opportunities: Regular Research Grants