Hypoglycemic effects of an aqueous extract of Bauhinia forficata on the salivary glands of diabetic mice

Autor(es)

Fudaba Curcio, Sergio Augusto ^[1] ; Bocchi Stefan, Luciana Francine ^[1] ; Randi, Bruno Azevedo ^[1] ; Dias, Marco Antonio ^[1] ; da Silva, Rodrigo Eduardo ^[1] ; Caldeira, Eduardo Jose ^[1]

Afiliação do(s) autor(es)

^[1] FMJ, Fac Med, Dept Morphol & Bas Pathol, Tissue Morphol Lab, Jundiai, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Pakistan Journal of Pharmaceutical Sciences; v. 25, n. 3, p. 493-499, JUL 2012.
• Citações Web of Science: 1

Resumo

The objective of this study was to evaluate the salivary glands in diabetic mice, analyzing alterations in the secretory epithelium and interactions with the stromal compartment acquired during a prolonged period of treatment with Bauhinia forficata extract. Female mice were divided into two groups: Nonobese diabetic (NOD) mice treated with Bauhinia forficata (I), and NOD mice not treated with the hypoglycemic agent (II). After treatment, the salivary glands were collected for analysis by transmitted and polarized light microscopy, complemented by three-dimensional analysis of these tissues. The results showed weight loss in animals of group II and weight recovery in treated animals. Glucose levels were elevated in group II, but declined in group I. In the two groups, the salivary glands were characterized by involution of the secretory epithelium, presence of an inflammatory infiltrate and an increase of extracellular fibrillar components. It can be concluded that treatment with Bauhinia forficata reduced glucose levels and contributed to weight recovery in treated animals. However, the observation of tissue destructuring and compromised epithelial-stromal interactions, with consequent impairment of glandular function, demonstrates that Bauhinia forficata exerts an effect on the recovery of body metabolism but this improvement does not influence in the tissue recovery. (AU)

• Processo FAPESP: 08/54241-0 - Efeitos do tratamento prolongado com bauhinia forficata sobre as glandulas salivares de camundongos espontaneamente diabeticos
• Beneficiário: Sergio Augusto Fudaba Curcio
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica