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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Hypoglycemic effects of an aqueous extract of Bauhinia forficata on the salivary glands of diabetic mice

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Author(s):
Fudaba Curcio, Sergio Augusto [1] ; Bocchi Stefan, Luciana Francine [1] ; Randi, Bruno Azevedo [1] ; Dias, Marco Antonio [1] ; da Silva, Rodrigo Eduardo [1] ; Caldeira, Eduardo Jose [1]
Total Authors: 6
Affiliation:
[1] FMJ, Fac Med, Dept Morphol & Bas Pathol, Tissue Morphol Lab, Jundiai, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Pakistan Journal of Pharmaceutical Sciences; v. 25, n. 3, p. 493-499, JUL 2012.
Web of Science Citations: 1
Abstract

The objective of this study was to evaluate the salivary glands in diabetic mice, analyzing alterations in the secretory epithelium and interactions with the stromal compartment acquired during a prolonged period of treatment with Bauhinia forficata extract. Female mice were divided into two groups: Nonobese diabetic (NOD) mice treated with Bauhinia forficata (I), and NOD mice not treated with the hypoglycemic agent (II). After treatment, the salivary glands were collected for analysis by transmitted and polarized light microscopy, complemented by three-dimensional analysis of these tissues. The results showed weight loss in animals of group II and weight recovery in treated animals. Glucose levels were elevated in group II, but declined in group I. In the two groups, the salivary glands were characterized by involution of the secretory epithelium, presence of an inflammatory infiltrate and an increase of extracellular fibrillar components. It can be concluded that treatment with Bauhinia forficata reduced glucose levels and contributed to weight recovery in treated animals. However, the observation of tissue destructuring and compromised epithelial-stromal interactions, with consequent impairment of glandular function, demonstrates that Bauhinia forficata exerts an effect on the recovery of body metabolism but this improvement does not influence in the tissue recovery. (AU)