INVESTIGATION OF THE MECHANISMS OF ACTION OF CRUDE EXTRACT OF BAUHINIA HOLOPHYLLA IN LIVER, SQUELETIC MUSCLE AND ADIPOSE TISSUE OF STREPTOZOTOCIN DIABETIC MICE

• Grant number: 13/10708-0
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: October 01, 2013
• End date: September 30, 2016
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: José Roberto Bosqueiro
• Grantee: Nathalia Aparecida de Paula Camaforte Henriques
• Host Institution: Faculdade de Ciências (FC). Universidade Estadual Paulista (UNESP). Campus de Bauru. Bauru , SP, Brazil
• Associated research grant: 09/52237-9 - Standardized herbal medicines for the treatment of chronic diseases, AP.BTA.TEM

Abstract

Diabetes Mellitus (DM) is known as a metabolic disease which affect 5% of people in the world. Characterized by fasting hyperglycemia (equal or higher than 126 mg/dL), involving alteration on carbohidrate, lipids and protein metabolism. Every year the number of diabetic people increases significatly, and also the research involving medicinal plants with properties hypoglycemic used by traditional medicine. However, in the literature there are few studies which identify the mechanism of action of these plants. Data in our laboratory showed that the treatment with crude extract of Bauhinia holophylla by 15 days, decreased the fasting glucose, lipds, and increased the content of hepatic glycogen. Furthermore, promoted the increase of expression of some protein involved in the insulin signaling pathway like AKT, p-AKT, PI3K and glycogen sinthase. Due to that, is very important a more detailed investigation about the mechanism of action of crude extract of Bauhinia holophylla.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE PAULA CAMAFORTE, NATHALIA AP; SALDANHA, LUIZ LEONARDO; PONCE VAREDA, PRISCILLA MARIA; REZENDE-NETO, JOAO M.; SENGER, MARIO R.; DELGADO, AISLAN Q.; MORGAN, HENRIQUE J. N.; VIOLATO, NATALIA MORETTI; PIERONI, LAIS GOYOS; DOKKEDAL, ANNE LIGIA; et al. Hypoglycaemic activity of Bauhinia holophylla through GSK3-beta inhibition and glycogenesis activation. Pharmaceutical Biology, v. 57, n. 1, p. 269-279, JAN 1 2019. (16/18628-4, 09/52237-9, 13/10708-0)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

HENRIQUES, Nathalia Aparecida de Paula Camaforte. Investigation of mechanisms of action of crude extract of Bauhinia holophylla in liver and muscle of diabetic STZ-induced mice. 2017. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Instituto de Biociências. Botucatu Botucatu.