Partial Replacement of omega-6 Fatty Acids With Medium-Chain Triglycerides, but Not Olive Oil, Improves Colon Cytokine Response and Damage in Experimental Colitis

Autor(es)

Bertevello, Pedro L. ^[1] ; De Nardi, Leticia ^[1] ; Torrinhas, Raquel S. ^[1] ; Logullo, Angela F. ^[2] ; Waitzberg, Dan L. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Med FMUSP, Dept Gastroenterol, Digest Surg Div LIM 35, BR-01243906 Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo, Paulista Sch Med UNIFESP EPM, Dept Pathol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Parenteral and Enteral Nutrition; v. 36, n. 4, p. 442-448, JUL 2012.
• Citações Web of Science: 11

Resumo

Background: Soybean oil is rich in omega-6 fatty acids, which are associated with higher incidence and more severe cases of inflammatory bowel diseases. The authors evaluated whether partial replacement of soybean oil by medium-chain triglycerides (MCTs) or olive oil influenced the incidence and severity of experimental ulcerative colitis by using different parenteral lipid emulsions (LEs). Methods: Wistar rats (n = 40) were randomized to receive parenteral infusion of the following LE: 100% soybean oil (SO), 50% MCT mixed with 50% soybean oil (MCT/SO), 80% olive oil mixed with 20% soybean oil (OO/SO), or saline (CC). After 72 hours of infusion, acetic acid experimental colitis was induced. After 24 hours, colon histology and cytokine expression were analyzed. Results: SO was not significantly associated with overall tissue damage. MCT/SO was not associated with necrosis (P < .005), whereas OO/SO had higher frequencies of ulcer and necrosis (P < .005). SO was associated with increased expression of interferon-gamma (P = .005) and OO/SO with increased interleukin (IL)-6 and decreased tumor necrosis factor-alpha expression (P < .05). MCT/SO appeared to decrease IL-1 (P < .05) and increase IL-4 (P < .001) expression. Conclusions: Parenteral SO with high concentration of omega-6 fatty acids was not associated with greater tissue damage in experimental colitis. SO partial replacement with MCT/SO decreased the frequency of histological necrosis and favorably modulated cytokine expression in the colon; however, replacement with OO/SO had unfavorable effects. (JPEN J Parenter Enteral Nutr. 2012; 36: 442-448) (AU)

• Processo FAPESP: 97/07971-7 - Efeitos de diferentes emulsões lipídicas no tratamento da colite inflamatória: estudo experimental em ratos
• Beneficiário: Dan Linetzky Waitzberg
• Modalidade de apoio: Auxílio à Pesquisa - Regular