The Value of Immunohistochemical Expression of BAX in Formulating a Prognosis for Canine Cutaneous Mast Cell Tumours

Autor(es)

Strefezzi, R. De F. ^[1] ; Kleeb, S. R. ^[2] ; Xavier, J. G. ^{[2, 3]} ; Fukumasu, H. ^[4] ; Catao-Dias, J. L. ^[5]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Zootecnia, Fac Zootecnia & Engn Alimentos, Pirassununga - Brazil

^[2] Univ Metodista Sao Paulo, Sao Bernardo Do Campo - Brazil

^[3] Univ Paulista, Pirassununga - Brazil

^[4] Univ Sao Paulo, Dept Ciencias Basicas, Fac Zootecnia & Engn Alimentos, Pirassununga - Brazil

^[5] Univ Sao Paulo, Dept Patol, Fac Med Vet & Zootecnia, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Comparative Pathology; v. 146, n. 4, p. 314-319, MAY 2012.
• Citações Web of Science: 5

Resumo

Irnmunohistochcmical expression of BAX was evaluated in 24 canine cutaneous mast cell tumours in order to verify the relationship of this expression to the histopathological grade of the lesions and its prognostic value for clinical outcome. BAX expression increased with higher histopathological grades (P = 0.0148; P < 0.05 between grades I and III). Animals with high levels of BAX expression were 4.25 times more likely to die from the disease and had shorter post-surgical survival times (P = 0.0009). These results suggest that alterations in BAX expression may be related to the aggressiveness of canine cutaneous mast cell tumours, indicating that immunohistochemical detection of BAX may be predictive of clinical outcome. (C) 2011 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 05/50407-3 - Indicadores prognósticos para mastocitomas: estudo morfométrico e imunoistoquímico
• Beneficiário: Jose Luiz Catao Dias
• Modalidade de apoio: Auxílio à Pesquisa - Regular