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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The Value of Immunohistochemical Expression of BAX in Formulating a Prognosis for Canine Cutaneous Mast Cell Tumours

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Author(s):
Strefezzi, R. De F. [1] ; Kleeb, S. R. [2] ; Xavier, J. G. [2, 3] ; Fukumasu, H. [4] ; Catao-Dias, J. L. [5]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Dept Zootecnia, Fac Zootecnia & Engn Alimentos, Pirassununga - Brazil
[2] Univ Metodista Sao Paulo, Sao Bernardo Do Campo - Brazil
[3] Univ Paulista, Pirassununga - Brazil
[4] Univ Sao Paulo, Dept Ciencias Basicas, Fac Zootecnia & Engn Alimentos, Pirassununga - Brazil
[5] Univ Sao Paulo, Dept Patol, Fac Med Vet & Zootecnia, Sao Paulo - Brazil
Total Affiliations: 5
Document type: Journal article
Source: Journal of Comparative Pathology; v. 146, n. 4, p. 314-319, MAY 2012.
Web of Science Citations: 5
Abstract

Irnmunohistochcmical expression of BAX was evaluated in 24 canine cutaneous mast cell tumours in order to verify the relationship of this expression to the histopathological grade of the lesions and its prognostic value for clinical outcome. BAX expression increased with higher histopathological grades (P = 0.0148; P < 0.05 between grades I and III). Animals with high levels of BAX expression were 4.25 times more likely to die from the disease and had shorter post-surgical survival times (P = 0.0009). These results suggest that alterations in BAX expression may be related to the aggressiveness of canine cutaneous mast cell tumours, indicating that immunohistochemical detection of BAX may be predictive of clinical outcome. (C) 2011 Elsevier Ltd. All rights reserved. (AU)