Synthesis and Anti-Mycobacterium tuberculosis Evaluation of Aza-Stilbene Derivatives

Autor(es)

Pavan, Fernando R. ^[1] ; de Carvalho, Gustavo Senra G. ^[2] ; da Silva, Adilson D. ^[2] ; Leite, Clarice Q. F. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista, Fac Ciencias Farmaceut, Araraquara, SP - Brazil

^[2] Univ Fed Juiz de Fora, Dept Quim, ICE, Juiz De Fora, MG - Brazil

• Tipo de documento: Artigo Científico
• Fonte: SCIENTIFIC WORLD JOURNAL; v. 11, p. 1113-1119, 2011.
• Citações Web of Science: 7

Resumo

Tuberculosis (TB) is a truly global disease, found in every country on earth. One-third of humanity, over 2 billion people, carry the bacillus that causes TB and 2 million people die of the disease each year. Despite that, no new specific drug against Mycobacterium tuberculosis has been developed since the 1960s. There are several candidates for new anti-TB agents, but none proven clinically effective. Stilbenes are compounds found in numerous medicinal plants and food products with some known biological and even antimycobacterial activity. This paper describes the synthesis and the anti-M. tuberculosis activity of eight stilbene analogues. The synthesis and characterization of these compounds are shown, and the results compared with one "first"-line drug used in current therapy. (AU)

• Processo FAPESP: 08/10390-2 - Determinação do perfil pré-clínico da atividade antituberculose in vitro e in vivo dos complexos de rutênio(II)fosfinas / diiminas
• Beneficiário: Fernando Rogério Pavan
• Modalidade de apoio: Bolsas no Brasil - Doutorado