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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Increased popliteal circumferential wall tension induced by orthostatic body posture is associated with local atherosclerotic plaques

Texto completo
Gemignani, Tiago [1] ; Azevedo, Renata C. [2] ; Higa, Celina M. [2] ; Coelho, Otavio R. [1] ; Matos-Souza, Jose R. [1] ; Nadruz, Jr., Wilson [1]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, Sch Med Sci, Dept Internal Med, BR-13081970 Campinas, SP - Brazil
[2] Univ Estadual Campinas, Sch Med Sci, Dept Med Psychol & Psychiat, BR-13081970 Sao Paulo, SP - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: ATHEROSCLEROSIS; v. 224, n. 1, p. 118-122, SEP 2012.
Citações Web of Science: 6

Objective: Lower limb arteries are exposed to higher hemodynamic burden in erectile posture. This study evaluated the effects of body posture on popliteal, carotid and brachial circumferential wall tension (CWT) and investigated the relationship between local CWT and atherosclerotic plaques in subjects with cardiovascular risk factors. Methods: Two hundred and three subjects (118 women and 85 men) with cardiovascular risk factors (smoking, hypertension or diabetes mellitus) underwent clinical and laboratory analysis and had their blood pressure measured in the arm and calf in supine and orthostatic positions. Arteries were evaluated by ultrasound analysis, while CWT was calculated according to Laplace's law. Results: Among the enrolled participants, 47%, 29% and none presented popliteal, carotid and brachial plaques, respectively. Carotid CWT measurements were not associated with local plaques after adjustment for potential confounders. Conversely, general linear model and logistic regression analyses adjusted for potential confounders demonstrated that peak orthostatic CWT was the only local hemodynamic parameter showing significant relationship with popliteal plaques in the whole sample. In gender-specific analyses, although positively correlated with popliteal plaques in both genders, local peak orthostatic CWT exhibited an independent association with popliteal plaques after adjustment for potential confounders only in women. Conclusion: Popliteal CWT measured in orthostatic posture, rather than in supine position, is associated with popliteal atherosclerotic plaques, particularly in women. These findings suggest that erectile posture might play a role in the atherogenesis of leg arteries by modifying local hemodynamic forces and that there may be gender differences in this regard. (c) 2012 Elsevier Ireland Ltd. All rights reserved. (AU)

Processo FAPESP: 10/16252-0 - Mecanismos envolvidos no aumento do risco cardiovascular em portadores de lesão da medula espinhal
Beneficiário:Wilson Nadruz Junior
Linha de fomento: Auxílio à Pesquisa - Regular