COMT polymorphisms as predictors of cognitive dysfunction during manic and mixed episodes in bipolar I disorder

Autor(es)

Soeiro-de-Souza, Marcio Gerhardt ^[1] ; Machado-Vieira, Rodrigo ^[2] ; Bio, Danielle Soares ^[1] ; Do Prado, Carolina Martins ^[2] ; Moreno, Ricardo Alberto ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo HC FMUSP, Mood Disorders Unit GRUDA, Dept & Inst Psychiat, Sch Med, BR-05403010 Sao Paulo - Brazil

^[2] Univ Sao Paulo HC FMUSP, Lab Neurosci LIM 27, Dept & Inst Psychiat, Sch Med, BR-05403010 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: BIPOLAR DISORDERS; v. 14, n. 5, p. 554-564, AUG 2012.
• Citações Web of Science: 17

Resumo

Soeiro-de-Souza MG, Machado-Vieira R, Soares Bio D, Do Prado CM, Moreno RA. COMT polymorphisms as predictors of cognitive dysfunction during manic and mixed episodes in bipolar I disorder. Bipolar Disord 2012: 14: 554564. (c) 2012 The Authors. ?Journal compilation (c) 2012 John Wiley \& Sons A/S. Objective: The dopaminergic system plays an important role in the prefrontal cortex (PFC) and is believed to mediate cognitive dysfunction (CD) in bipolar disorder (BD). The enzyme catechol-O-methyltransferase (COMT) is involved in the catabolism of dopamine in the PFC, and an association between COMT single nucleotide polymorphisms (SNPs) and BD has been reported. COMT SNPs have also been associated with executive and working memory performance in healthy subjects, patients with schizophrenia, and euthymic BD patients. The objective of this study was to investigate the association between COMT SNPs and acute CD during BD mood episodes. Methods: Seventy-two symptomatic, medication-free subjects with bipolar I disorder (BD-I) and 76 healthy controls were evaluated using neuropsychological tests, and genotyped for COMT SNPs rs4680 and rs165599. Results: Patients undergoing mania and mixed episodes carrying the COMT allele G had better performance on executive function, memory, verbal fluency, and intelligence tests. Moreover, an interaction was detected between the COMT allele G and the Young Mania Rating Scale in BD CD. Conclusions: Allele G from COMT SNPs rs4680 and rs165599 may represent reliable state-dependent predictors of global CD during manic and mixed episodes in BD. Further studies in larger samples are necessary to confirm these findings. (AU)

• Processo FAPESP: 10/06230-0 - Estudo genético de associação entre polimorfismos de nucleotídeo único e desempenho cognitivo em pacientes bipolares tipo I jovens: Licavalgene
• Beneficiário: Ricardo Alberto Moreno
• Modalidade de apoio: Auxílio à Pesquisa - Regular