Additional chromosomal abnormalities detected by array comparative genomic hybridization in AML

Autor(es)

Costa, Ana Rosa S. ^[1] ; Belangero, Sintia I. ^[2] ; Melaragno, Maria Isabel ^[2] ; Chauffaille, Maria de Lourdes ^[1]

Afiliação do(s) autor(es)

^[1] UNIFESP Escola Paulista Med, Div Hematol & Hemotherapy, BR-04023900 Sao Paulo - Brazil

^[2] UNIFESP Escola Paulista Med, Div Genet, BR-04023900 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: MEDICAL ONCOLOGY; v. 29, n. 3, p. 2083-2087, SEP 2012.
• Citações Web of Science: 2

Resumo

Improved outcome of acute myeloid leukemia (AML) depends on the better differentiation of subtypes to predict treatment response and the identification of new target for treatment. In this study, array comparative genomic hybridization (aCGH) was used to distinguish eight cases of AML cases. Validation was performed by FISH and quantitative genomic PCR. The aCGH revealed new large and small recurrent genomic imbalances, such as gains of 1p36, 10q26, 11p15, 20q13, 22q23, harboring many proto-oncogenes. These results better define genetically the studied cases and could be used to understand the multiple phenomena involved in leukemogenesis. (AU)

• Processo FAPESP: 07/55665-6 - Hibridação genômica comparativa e arranjos (CGHA) em leucemia mielóide aguda
• Beneficiário: Maria de Lourdes Lopes Ferrari Chauffaille
• Modalidade de apoio: Auxílio à Pesquisa - Regular