HIV-1 Proviral DNA Loads (as Determined by Quantitative PCR) in Patients Subjected to Structured Treatment Interruption after Antiretroviral Therapy Failure

Autor(es)

Komninakis, Shirley V. ^[1] ; Santos, Domingos E. M. ^[1] ; Santos, Carlos ^[2] ; Oliveros, Marcia P. R. ^[3] ; Sanabani, Sabri ^[4] ; Diaz, Ricardo S. ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Fed Univ Sao Paulo UNIFESP, Div Infect Dis, Retrovirol Lab, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Lab Ctr Genomas, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Sch Med, Discipline Informat Technol, Sao Paulo - Brazil

^[4] Univ Sao Paulo, Dept Biol Mol, Fundacao Prosangue Hemoctr Sao Paulo, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Clinical Microbiology; v. 50, n. 6, p. 2132-2133, JUN 2012.
• Citações Web of Science: 4

Resumo

The impact of Structured Treatment Interruption (STI) in peripheral blood mononuclear cell (PBMC) proviral reservoirs in 41 highly active antiretroviral therapy (HAART)-treated viremic individuals at baseline and 12 weeks after STI was determined using quantitative PCR (qPCR). Viral load increased 0.7 log(10) and CD4 decreased 97.5 cells/mm(3) after 12 weeks. A total of 28 of the 41 individuals showed an increased proviral load, 19 with a statistically significant increase above 10%. An increase in active viral replication is an important factor in the replenishment of the proviral reservoir even for short time periods. (AU)

• Processo FAPESP: 03/11781-1 - Monitorização da carga proviral do HIV-1 em pacientes recebendo terapia antiretroviral combinada e associação com a progressão da doença
• Beneficiário: Shirley Cavalcante Vasconcelos
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado