| Full text | |
| Author(s): |
Komninakis, Shirley V.
[1]
;
Santos, Domingos E. M.
[1]
;
Santos, Carlos
[2]
;
Oliveros, Marcia P. R.
[3]
;
Sanabani, Sabri
[4]
;
Diaz, Ricardo S.
[1, 2]
Total Authors: 6
|
| Affiliation: | [1] Fed Univ Sao Paulo UNIFESP, Div Infect Dis, Retrovirol Lab, Sao Paulo - Brazil
[2] Univ Sao Paulo, Lab Ctr Genomas, Sao Paulo - Brazil
[3] Univ Sao Paulo, Sch Med, Discipline Informat Technol, Sao Paulo - Brazil
[4] Univ Sao Paulo, Dept Biol Mol, Fundacao Prosangue Hemoctr Sao Paulo, Sao Paulo - Brazil
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | Journal of Clinical Microbiology; v. 50, n. 6, p. 2132-2133, JUN 2012. |
| Web of Science Citations: | 4 |
| Abstract | |
The impact of Structured Treatment Interruption (STI) in peripheral blood mononuclear cell (PBMC) proviral reservoirs in 41 highly active antiretroviral therapy (HAART)-treated viremic individuals at baseline and 12 weeks after STI was determined using quantitative PCR (qPCR). Viral load increased 0.7 log(10) and CD4 decreased 97.5 cells/mm(3) after 12 weeks. A total of 28 of the 41 individuals showed an increased proviral load, 19 with a statistically significant increase above 10%. An increase in active viral replication is an important factor in the replenishment of the proviral reservoir even for short time periods. (AU) | |