| Texto completo | |
| Autor(es): |
Ramos, Rodrigo Nalio
[1]
;
Oliveira, Carine Ervolino
[1]
;
Gasparoto, Thais Helena
[1]
;
de Souza Malaspina, Tatiana Salles
[1]
;
Belai, Eduardo Bertoli
[1]
;
Cavassani, Karen Angelica
[2]
;
Garlet, Gustavo Pompermaier
[1]
;
da Silva, Joao Santana
[3]
;
Campanelli, Ana Paula
[1]
Número total de Autores: 9
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Dept Biol Sci, Bauru Sch Dent, BR-17012901 Bauru, SP - Brazil
[2] Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI - USA
[3] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Biochem & Immunol, BR-14049 Ribeirao Preto, SP - Brazil
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Carcinogenesis; v. 33, n. 4, p. 902-909, APR 2012. |
| Citações Web of Science: | 10 |
| Resumo | |
Squamous cell carcinoma (SCC) constitutes a microenvironment that could modulate the antitumor immune response. Also, tumor-infiltrating lymphocytes are believed to play complex regulatory roles in antitumor immunity against SCC. The presence of regulatory T cells (Tregs) has been associated with the suppression of tumor-reactive T cells. However, the underlying mechanism for this T cell dysfunction is not clear. We used a multistage model of SCC to examine the role of Treg cells during tumor development. 7,12-dimethylbenz{[}a]-anthracene/phorbol 12-myristate 13-acetate treatment and systemic depletion of Treg cells using an anti-CD25 monoclonal antibody (PC61) resulted in a decrease in the number and incidence of papilloma. Furthermore, CD25 depletion increased the proportion of CD8(+) and CD4(+) T cells that were isolated from tumor lesions. The levels of interleukin (IL)-1 beta, IL-10, IL-12, IL-13, interferon-gamma, transforming growth factor-beta and tumor necrosis factor-alpha, but not IL-17, were increased in the tumor microenvironment after Treg depletion. Therefore, our results indicated involvement of CD25(+) T cells in SCC development and in the suppression of the inflammatory immune response. (AU) | |
| Processo FAPESP: | 08/10999-7 - Modulação da resposta imune durante o desenvolviemnto de carcinoma espinocelular |
| Beneficiário: | Ana Paula Campanelli |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 06/01617-8 - Estudo do papel de células T regulatórias no desenvolvimento de carcinoma oral de células escamosas |
| Beneficiário: | Rodrigo Nalio Ramos |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |
| Processo FAPESP: | 09/14127-7 - O papel do inflamassoma nos tumores quimicamente induzidos |
| Beneficiário: | Thaís Helena Gasparoto |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 09/03471-9 - Modulação da resposta imune durante o desenvolvimento de carcinoma espinocelular |
| Beneficiário: | Eduardo Bertoli Belai |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |
| Processo FAPESP: | 12/03859-0 - CD25 T cell depletion impairs murine squamous cell carcinoma development via modulation of antitumor immune responses |
| Beneficiário: | Ana Paula Campanelli |
| Modalidade de apoio: | Auxílio à Pesquisa - Publicações científicas - Artigo |