Hip circumference is associated with high density lipoprotein cholesterol response following statin therapy in hypertensive subjects

Autor(es)

Pio-Magalhaes, J. A. ^[1] ; Ferreira-Sae, M. C. ^[1] ; Souza, F. A. ^[1] ; Grespan-Magossi, A. M. ^[1] ; Schreiber, R. ^[1] ; Velloso, L. A. ^[1] ; Geloneze, B. ^[1] ; Franchini, K. G. ^[1] ; Nadruz, Jr., W. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Dept Internal Med, Sch Med, Campinas - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Endocrinological Investigation; v. 34, n. 9, p. 680-684, OCT 2011.
• Citações Web of Science: 1

Resumo

Aim: This report investigated the relationship between anthropometric measurements of body fat distribution and lipid response to statins in hypercholesterolemic hypertensive patients. Methods: We prospectively examined 129 subjects who used either simvastatin 20 mg/day (no.=83) or atorvastatin 10 mg/day (no.=46) for 3 months. Anthropometry included evaluation of body mass index, waist and hip circumferences, and waist-to-hip-ratio. Results: Significant decreases in LDL (p<0.001), total cholesterol (p<0.001), and triglycerides (p=0.04) levels were detected after 3 months of therapy in the whole sample. At baseline, only an inverse correlation between waist circumference and HDL-cholesterol levels was detected (r=-0.18; p=0.04). Conversely, a direct relationship between hip circumference and HDL-cholesterol response to statins was found in the whole sample (r=0.24; p=0.006), while no other anthropometric measurement displayed significant correlation with lipid changes. The association between HDL-cholesterol response and hip circumference was further confirmed by stepwise regression analysis adjusted for baseline HDL-cholesterol levels, metabolic syndrome, body mass index, and waist circumference. Conclusions: Hip circumference, a surrogate marker of peripheral adiposity, is associated with HDL-cholesterol changes following statin therapy in hypertensive patients. (J. Endocrinol. Invest. 34: 680-684, 2011) (C) 2011, Editrice Kurtis (AU)

• Processo FAPESP: 05/56986-5 - Mecanotransdução vascular: implicações na aterogênese
• Beneficiário: Wilson Nadruz Junior
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores