| Texto completo | |
| Autor(es): Mostrar menos - |
Schreiber, Roberto
[1]
;
Ferreira-Sae, Maria C.
[1]
;
Ronchi, Juliana A.
[2]
;
Pio-Magalhaes, Jose A.
[1]
;
Cipolli, Jose A.
[1]
;
Matos-Souza, Jose R.
[1]
;
Mill, Jose G.
[3]
;
Vercesi, Anibal E.
[2]
;
Krieger, Jose E.
[4]
;
Franchini, Kleber G.
[1]
;
Pereira, Alexandre C.
[4]
;
Nadruz Junior, Wilson
[1]
Número total de Autores: 12
|
| Afiliação do(s) autor(es): | [1] Univ Estadual Campinas, Dept Internal Med, Campinas, SP - Brazil
[2] Univ Estadual Campinas, Dept Clin Pathol, Campinas, SP - Brazil
[3] Univ Fed Espirito Santo, Vitoria - Brazil
[4] Univ Sao Paulo, Heart Inst InCor, Lab Genet & Mol Cardiol, Sao Paulo - Brazil
Número total de Afiliações: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | BMC MEDICAL GENETICS; v. 12, AUG 31 2011. |
| Citações Web of Science: | 14 |
| Resumo | |
Background: Reactive oxygen species have been implicated in the physiopathogenesis of hypertensive end-organ damage. This study investigated the impact of the C242T polymorphism of the p22-phox gene (CYBA) on left ventricular structure in Brazilian hypertensive subjects. Methods: We cross-sectionally evaluated 561 patients from 2 independent centers {[}Campinas (n = 441) and Vitoria (n = 120)] by clinical history, physical examination, anthropometry, analysis of metabolic and echocardiography parameters as well as p22-phox C242T polymorphism genotyping. In addition, NADPH-oxidase activity was quantified in peripheral mononuclear cells from a subgroup of Campinas sample. Results: Genotype frequencies in both samples were consistent with the Hardy-Weinberg equilibrium. Subjects with the T allele presented higher left ventricular mass/height(2.7) than those carrying the CC genotype in Campinas (76.8 +/- 1.6 vs 70.9 +/- 1.4 g/m(2.7); p = 0.009), and in Vitoria (45.6 +/- 1.9 vs 39.9 +/- 1.4 g/m(2.7); p = 0.023) samples. These results were confirmed by stepwise regression analyses adjusted for age, gender, blood pressure, metabolic variables and use of anti-hypertensive medications. In addition, increased NADPH-oxidase activity was detected in peripheral mononuclear cells from T allele carriers compared with CC genotype carriers (p = 0.03). Conclusions: The T allele of the p22-phox C242T polymorphism is associated with higher left ventricular mass/height(2.7) and increased NADPH-oxidase activity in Brazilian hypertensive patients. These data suggest that genetic variation within NADPH-oxidase components may modulate left ventricular remodeling in subjects with systemic hypertension. (AU) | |
| Processo FAPESP: | 10/16252-0 - Mecanismos envolvidos no aumento do risco cardiovascular em portadores de lesão da medula espinhal |
| Beneficiário: | Wilson Nadruz Junior |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |