Dual Effects of Hyperprolactinemia on Carrageenan-Induced Inflammatory Paw Edema in Rats

Autor(es)

Ochoa-Amaya, Julieta E. ^[1] ; Malucelli, Benjamin E. ^[2] ; Cruz-Casallas, Pablo E. ^[3] ; Nasello, Antonia G. ^[4] ; Felicio, Luciano F. ^[2] ; Carvalho-Freitas, Maria I. R. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Llanos, Fac Ciencias Agropecuarias & Recursos Nat, Escuela Med Vet & Zootecnia, Villavicencio - Colombia

^[2] Univ Sao Paulo, Fac Med Vet & Zootecnia, Dept Patol, BR-05508900 Sao Paulo - Brazil

^[3] Univ Llanos, Inst Acuicultura, Villavicencio - Colombia

^[4] Fac Ciencias Med Santa Casa Sao Paulo, Dept Ciencias Fisiol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: NEUROIMMUNOMODULATION; v. 18, n. 4, p. 245-253, 2011.
• Citações Web of Science: 9

Resumo

Objectives: The effects of short-term 5-day and long-term 30-day hyperprolactinemia induced by domperidone (1.7 mg/kg/day, s.c.) or ectopic pituitary graft on the acute inflammatory response induced by carrageenan were evaluated in male rats. Both models of hyperprolactinemia effectively increased serum prolactin (PRL) levels. Methods: The volume in milliliters of inflammatory edema was measured by plethysnnography 1, 2, 3, 4, 6, 8 and 24 h after carrageenan injection. The areas under the inflammatory time-response curves were compared. Additionally, the effects of hyperprolactinemia on body weight and serum corticosterone levels were evaluated. Results: In both domperidone-treated and pituitary graft-implanted animals, short-term 5-day hyperprolactinemia increased the inflammatory response, while long-term 30-day hyperprolactinemia had anti-inflammatory effects. Body weight was not affected by either short- or long-term hyperprolactinennia. Conclusion: These results show that PRL has biphasic effects on the carrageenan-induced inflammatory response. Copyright (C) 2011 S. Karger AG, Basel (AU)

• Processo FAPESP: 07/04224-0 - Efeitos da administração de interleucina-2 no comportamento maternal e na liberação in vivo de dopamina em núcleo accumbens de ratas
• Beneficiário: Luciano Freitas Felicio
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 96/12461-5 - Efeitos da prolactina e do estresse sobre a resposta inflamatória induzida pela carragenina em ratos
• Beneficiário: Julieta Esperanza Ochoa Amaya
• Modalidade de apoio: Bolsas no Brasil - Mestrado